INT142080

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.47
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IDO1) small molecule metabolic process (IDO1) oxidoreductase activity (IDO1)
cellular nitrogen compound metabolic process (IDO1)
IDO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 93.08 High High
Central nervous system 6 91.76 High High
headache 9 86.80 High High
cytokine 6 86.76 High High
tolerance 8 35.04 Quite Low
cva 4 25.00 Low Low
Migraine 1 25.00 Low Low
abatacept 3 9.28 Low Low
fibrosis 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 10 97.68 Very High Very High Very High
INFLAMMATION 5 93.08 High High
Apoptosis 1 90.16 High High
Headache 10 86.80 High High
Urinary Tract Disease 1 81.88 Quite High
Immunodeficiency 2 75.00 Quite High
Cerebral Toxoplasmosis 2 75.00 Quite High
Lymphadenopathy 1 75.00 Quite High
Neurogenic Inflammation 1 75.00 Quite High
Rupture 1 68.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, which stimulates the indoleamine 2,3-dioxygenase (IDO) to degrade tryptophan.
Protein_catabolism (degrade) of IDO
1) Confidence 0.27 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.09 Pain Relevance 0
This is consistent with significantly lower enzyme indoleamine 2,3-dioxygenase (IDO) activity reported in atopic than in nonatopic individuals, and an important role that IDO and tryptophan degradation pathways plays in both, the host resistance to T. gondii infection and its reactivation.
Protein_catabolism (degradation) of IDO associated with infection
2) Confidence 0.21 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 1.38 Pain Relevance 0.55

General Comments

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