INT142081

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.55
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IDO1) small molecule metabolic process (IDO1) oxidoreductase activity (IDO1)
cellular nitrogen compound metabolic process (IDO1)
Anatomy Link Frequency
monocytes 1
fibroblasts 1
IDO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 5 97.36 Very High Very High Very High
cINOD 42 93.56 High High
cytokine 10 92.52 High High
Inflammation 20 90.48 High High
cva 4 82.64 Quite High
headache 18 75.00 Quite High
Central nervous system 14 54.40 Quite High
Migraine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 93.08 High High
Toxicity 1 83.72 Quite High
Pseudotumor Cerebri 4 83.52 Quite High
Cancer 5 80.68 Quite High
Viral Meningitis 2 78.48 Quite High
Headache 20 75.00 Quite High
Immunodeficiency 4 75.00 Quite High
Cerebral Toxoplasmosis 4 75.00 Quite High
Neurogenic Inflammation 2 75.00 Quite High
Lymphadenopathy 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, these experiments, which demonstrate that Indo does not induce a change in FRET efficiency in DOPC membranes also demonstrated that Indo did not directly interact with the probes and did not affect their inherent fluorescent properties.


Indo Neg (not) Binding (interact) of
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809093 Disease Relevance 0 Pain Relevance 0.08
Interestingly, Indo is highly amphiphilic and associates strongly with lipid membranes, which influence localization, structure and function of membrane-associating proteins and actively regulate cell signaling events.
Indo Binding (associates) of
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2809093 Disease Relevance 0.17 Pain Relevance 0.22
On the other hand, IL-4 and TGF-beta can suppress IDO activity in some cells, for example human monocytes and fibroblasts, which is consistent with metabolic pathways controlled by IDO being a significant contributor to the proinflammatory system.
IDO Binding (activity) of in fibroblasts
3) Confidence 0.12 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 1.03 Pain Relevance 0.59
Here the safety information available for 5 dietary putative chemopreventive compounds, indole-3-carbinol (I3C), curcumin, quercetin, epigallocatechin gallate (EGCG), and capsaicin is reviewed.
indole-3-carbinol Binding (compounds) of associated with qutenza
4) Confidence 0.10 Published 2007 Journal Nutr Cancer Section Abstract Doc Link 18001209 Disease Relevance 0.31 Pain Relevance 0.24
On the other hand, IL-4 and TGF-beta can suppress IDO activity in some cells, for example human monocytes and fibroblasts, which is consistent with metabolic pathways controlled by IDO being a significant contributor to the proinflammatory system.
IDO Binding (activity) of in monocytes
5) Confidence 0.04 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 1.03 Pain Relevance 0.59

General Comments

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