INT142082

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 9.46
Pain Relevance 6.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IDO1) small molecule metabolic process (IDO1) oxidoreductase activity (IDO1)
cellular nitrogen compound metabolic process (IDO1)
Anatomy Link Frequency
T-cell 4
nerve 3
brain 1
bladders 1
IDO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 435 100.00 Very High Very High Very High
cytokine 417 100.00 Very High Very High Very High
abatacept 27 99.92 Very High Very High Very High
cva 2 98.12 Very High Very High Very High
Serotonin 2 97.64 Very High Very High Very High
cINOD 21 96.96 Very High Very High Very High
spastic colon 14 92.56 High High
Pain 153 90.40 High High
COX2 8 89.68 High High
monoamine 2 88.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 483 100.00 Very High Very High Very High
Bladder Disease 170 100.00 Very High Very High Very High
Communicable Diseases 44 99.48 Very High Very High Very High
Encephalopathy 54 98.88 Very High Very High Very High
Viral Meningitis 1 98.60 Very High Very High Very High
Influenza Virus Infection 24 98.28 Very High Very High Very High
Pseudotumor Cerebri 2 98.12 Very High Very High Very High
Rheumatoid Arthritis 5 97.92 Very High Very High Very High
Malaria 420 96.32 Very High Very High Very High
Overactive Bladder 130 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of abatacept on T-cell proliferation was not through induction of IDO activity, as no increase in IDO mRNA or kynurenine was observed and 1-methyl-D-tryptophan did not reverse the inhibition.
Neg (no) Positive_regulation (increase) of IDO in T-cell associated with abatacept
1) Confidence 0.60 Published 2008 Journal Clin. Immunol. Section Abstract Doc Link 17945538 Disease Relevance 0.09 Pain Relevance 0.87
The effect of abatacept on T-cell proliferation was not through induction of IDO activity, as no increase in IDO mRNA or kynurenine was observed and 1-methyl-D-tryptophan did not reverse the inhibition.
Positive_regulation (induction) of IDO in T-cell associated with abatacept
2) Confidence 0.60 Published 2008 Journal Clin. Immunol. Section Abstract Doc Link 17945538 Disease Relevance 0.09 Pain Relevance 0.86
Tryptophan forms the substrate for serotonin biosynthesis, but it can alternatively be catabolized to kynurenine (Kyn) by the enzyme indoleamine 2,3-dioxygenase (IDO), the main inducer of which is interferon-gamma.
Positive_regulation (inducer) of IDO associated with serotonin
3) Confidence 0.49 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18823288 Disease Relevance 0.22 Pain Relevance 0.64
Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction.
Positive_regulation (induction) of IDO in T-cell associated with abatacept
4) Confidence 0.40 Published 2008 Journal Clin. Immunol. Section Title Doc Link 17945538 Disease Relevance 0.10 Pain Relevance 0.97
resulted in induction of IDO activity in both cell populations, with a lower level in T-MPCs (Figure 5b).
Positive_regulation (induction) of IDO
5) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0 Pain Relevance 0
via its induction of indoleamine 2,3-dioxygenase (IDO), an enzyme involved in the catabolism of tryptophan, an essential amino acid required for protein synthesis and T-cell proliferation [12,13].
Positive_regulation (induction) of IDO in T-cell
6) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0.47 Pain Relevance 0.08
Kynurenine levels in the supernatants are directly proportional to IDO activity.
Positive_regulation (proportional) of IDO
7) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0 Pain Relevance 0.03
inducible IDO activity was higher in IFN?
Positive_regulation (inducible) of IDO
8) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.06 Pain Relevance 0.09
to stimulate IDO activity by T-MPCs compared with BM-MPCs.


Positive_regulation (stimulate) of IDO
9) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0.07 Pain Relevance 0.08
Additionally, we tested the ability of increasing Indo concentrations to alter the detergent resistance of DPPC or DOPC exposed to a fixed triton X-100 level.
Positive_regulation (increasing) of Indo
10) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809093 Disease Relevance 0 Pain Relevance 0.17
In addition, an increase in TRPM8-immunoreactive nerve fibres in IDO and PBS, suggests that TRPM8 may contribute to the increased frequency which is a prominent symptom in these conditions.
Positive_regulation (increase) of IDO in nerve associated with bladder disease
11) Confidence 0.18 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.65 Pain Relevance 0.20
Also, it seems that idiopathic intracranial hypertension, pseudotumor cerebri, and aseptic meningitis, induced by various factors, may result from their interference with IDO and inducible nitric oxide synthase activities, endogenous NO level, and cytokine irregularities which finally affect former T. gondii status 2mo in the brain.
Positive_regulation (inducible) of IDO in brain associated with cva, viral meningitis, pseudotumor cerebri and cytokine
12) Confidence 0.15 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 1.41 Pain Relevance 0.69
The presence of increased immunoreactivity in nerve bundles may indicate increased levels of axonally transported TRPM8 in IDO and PBS bladders.
Positive_regulation (increased) of IDO in bladders associated with bladder disease
13) Confidence 0.13 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.51 Pain Relevance 0.53
The myelin stained fibres also showed a two-fold increase in the PBS and IDO groups, but this was not statistically significant (PBS, P = 0.143, IDO, P = 0.076; Fig 3d).
Positive_regulation (increase) of IDO associated with bladder disease
14) Confidence 0.12 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.76 Pain Relevance 0.17
On separately analysing the TRPM8-immunoreactive fine-calibre axons, a significant increase, similar to total nerve fibres was seen in the IDO (P = 0.0246) and PBS (P < 0.0001) groups (Fig 3c).
Positive_regulation (increase) of IDO in nerve associated with bladder disease
15) Confidence 0.12 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.59 Pain Relevance 0.08
There was marked increase of TRPM8-immunoreactive nerve fibres in IDO (P = 0.0249) and PBS (P < 0.0001) specimens, compared with controls.
Positive_regulation (increase) of IDO in nerve
16) Confidence 0.12 Published 2006 Journal BMC Urol Section Abstract Doc Link PMC1420318 Disease Relevance 0.53 Pain Relevance 0.35
So too, as reviewed recently elsewhere [315], does the induction, by inflammatory cytokines, of indoleamine 2,3-dioxygenase (IDO), a rate-limiting enzyme in the L-tryptophan-kynurenine pathway, which converts L-tryptophan, an essential amino acid, to N-formylkynurenine.
Positive_regulation (induction) of IDO associated with inflammation and cytokine
17) Confidence 0.09 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.91 Pain Relevance 0.25
Hyperphenylalanaemia and IDO induction in systemic infectious diseases
Positive_regulation (induction) of IDO associated with communicable diseases
18) Confidence 0.05 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.70 Pain Relevance 0.26

General Comments

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