INT142083

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.86
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AIF1) plasma membrane (AIF1) cytoskeleton (AIF1)
nucleus (AIF1) response to stress (AIF1) cytoplasm (AIF1)
Anatomy Link Frequency
microglia 2
macrophage 1
brain 1
AIF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 100.00 Very High Very High Very High
cytokine 29 95.52 Very High Very High Very High
Neurobehavioral 14 83.12 Quite High
headache 9 75.00 Quite High
chemokine 16 59.60 Quite High
cva 2 58.24 Quite High
Central nervous system 14 42.24 Quite Low
Migraine 1 25.00 Low Low
glial activation 14 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 27 100.00 Very High Very High Very High
Infection 107 99.36 Very High Very High Very High
Targeted Disruption 24 97.52 Very High Very High Very High
Hepatitis C Virus Infection 378 96.48 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 190 92.16 High High
Drug Induced Neurotoxicity 24 79.44 Quite High
Headache 10 75.00 Quite High
Immunodeficiency 6 75.00 Quite High
Cerebral Toxoplasmosis 2 75.00 Quite High
Lymphadenopathy 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To quantify the degree of IBA-1 upregulation induced by SIV infection in CD8-depleted animals, immunohistochemistry computer image analysis was performed on brain sections from uninfected, CD8-depleted control animals along with those from the two SIV-infected, persistently CD8-depleted cohorts, of which included one cohort that was MN-treated and one untreated cohort.
Positive_regulation (upregulation) of IBA-1 in brain associated with infection
1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.15 Pain Relevance 0
Calcium binding adaptor protein 1, IBA-1 is expressed by resting microglia and is upregulated when these cells are activated [27].
Positive_regulation (upregulated) of IBA-1 in microglia
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.06 Pain Relevance 0
Morphological analysis at day 14 post-implantation disclosed increased immunoreactivity of GFAP, an astrocyte marker, and Iba-1, a microglia/macrophage marker, in the right striatum of Vpr-transgenic mice receiving HCV core protein implantation (Figure 7Aiv and v).
Positive_regulation (increased) of Iba-1 in macrophage associated with targeted disruption and hepatitis c virus infection
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.83 Pain Relevance 0.10
Morphological analysis at day 14 post-implantation disclosed increased immunoreactivity of GFAP, an astrocyte marker, and Iba-1, a microglia/macrophage marker, in the right striatum of Vpr-transgenic mice receiving HCV core protein implantation (Figure 7Aiv and v).
Positive_regulation (increased) of Iba-1 in microglia associated with targeted disruption and hepatitis c virus infection
4) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.83 Pain Relevance 0.10
Moreover, NO inhibits IDO activity, thereby suppressing kynurenine formation, and at least one member of the kynurenine pathway, 3-hydroxyanthranilic acid, has been shown to inhibit NOS enzyme activity, the expression of NOS mRNA, and activation of the inflammatory transcription factor, nuclear factor-kB.
Positive_regulation (activation) of inflammatory transcription factor associated with inflammation
5) Confidence 0.00 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 1.00 Pain Relevance 0.57

General Comments

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