INT142112

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.46
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
cleavage 2
mouth 2
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 2 100.00 Very High Very High Very High
palliative 1 91.16 High High
amygdala 3 85.56 High High
Potency 2 84.48 Quite High
Hippocampus 21 83.08 Quite High
metalloproteinase 2 79.04 Quite High
cerebral cortex 6 70.24 Quite High
depression 4 66.92 Quite High
Central nervous system 28 46.48 Quite Low
Pyramidal cell 4 27.12 Quite Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 14 100.00 Very High Very High Very High
Neurodegenerative Disease 21 99.64 Very High Very High Very High
Disease 242 98.48 Very High Very High Very High
Necrosis 5 87.72 High High
Cancer 3 87.36 High High
Cognitive Disorder 20 83.20 Quite High
Toxicity 7 78.32 Quite High
Diabetes Mellitus 100 76.64 Quite High
Depression 4 66.92 Quite High
Amnesia 2 60.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-secretase responsible for regulated APP cleavage [47].
Regulation (responsible) of Regulation (regulated) of APP in cleavage
1) Confidence 0.39 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.23 Pain Relevance 0.08
Glucose metabolism and insulin receptor mediated signal transduction control the activity of several enzymes involved in the generation of the APP derivative A?
Regulation (involved) of Regulation (generation) of APP
2) Confidence 0.34 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.41 Pain Relevance 0.06
Mutations in the APP gene, which is located on chromosome 21, have been postulated to play a major role in the aggregation of a clumped sticky protein fragment known as A?
Spec (postulated) Regulation (postulated) of Regulation (Mutations) of APP
3) Confidence 0.34 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.11 Pain Relevance 0.19
Biochemical and crystallographic studies of AChE revealed two potential binding sites in the active-site gorge of AChE, one of which, the "peripheral anionic site" at the mouth of the gorge, was implicated in promoting aggregation of the beta amyloid (Abeta) peptide responsible for the neurodegenerative process in AD.
Regulation (aggregation) of Regulation (responsible) of Abeta in mouth associated with alzheimer's dementia, disease, neurodegenerative disease and abeta
4) Confidence 0.02 Published 2007 Journal Curr Top Med Chem Section Abstract Doc Link 17305579 Disease Relevance 0.70 Pain Relevance 0.26

General Comments

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