INT142117

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.75
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx2) DNA binding (Runx2) transcription factor binding (Runx2)
cytoplasm (Runx2)
Anatomy Link Frequency
TMJ 1
hypertrophic chondrocytes 1
Runx2 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 91 90.40 High High
Pain 7 58.08 Quite High
Snapping jaw 10 50.00 Quite Low
Kinase C 2 21.12 Low Low
antagonist 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 77 99.68 Very High Very High Very High
Targeted Disruption 9 97.48 Very High Very High Very High
Cleidocranial Dysplasia 93 96.00 Very High Very High Very High
Dislocations 3 94.64 High High
Joint Instability 9 93.92 High High
Temporomandibular Joint Syndrome 10 93.68 High High
Mixed Connective Tissue Disorder 6 92.40 High High
Aging 13 92.32 High High
Osteoarthritis 96 90.40 High High
Learning Disorders 6 89.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Estrogen plays important roles in the metabolism and maintenance of TMJ via regulations of signaling molecules such as BMP-4, Runx2, and BSP.
Regulation (regulations) of Runx2 in TMJ
1) Confidence 0.61 Published 2007 Journal Oral Dis Section Body Doc Link 17305626 Disease Relevance 0.07 Pain Relevance 0
This result maps the breakpoint on chromosome 6p21 to a region approximately 50 kb upstream of the RUNX2 gene based on the genetic mapping position of G248P80212A10 and RUNX2 on the UCSC genome website.
Regulation (based) of RUNX2
2) Confidence 0.45 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0 Pain Relevance 0
We identified a complex translocation involving three chromosomes and carried out further molecular investigations to determine the integrity of the RUNX2 gene on 6p21 (region involved in the translocation), which has been implicated in the causation of CCD.


Spec (determine) Regulation (integrity) of RUNX2 associated with cleidocranial dysplasia
3) Confidence 0.45 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 1.08 Pain Relevance 0.06
The translocation of the RUNX2 gene on 6p to chromosome 21 in our patient may have disrupted a 5?
Regulation (translocation) of RUNX2
4) Confidence 0.45 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.27 Pain Relevance 0
We examined the significant alterations of the expression patterns of bone morphogenetic protein (BMP)-4, Runx2, and bone sialoprotein (BSP) after ovariectomy.
Spec (examined) Regulation (alterations) of Runx2
5) Confidence 0.45 Published 2007 Journal Oral Dis Section Body Doc Link 17305626 Disease Relevance 0.09 Pain Relevance 0
RUNX2 is a transcription factor up-regulated during osteoblast differentiation, and is also expressed by some hypertrophic chondrocytes [35].
Regulation (regulated) of RUNX2 in hypertrophic chondrocytes associated with osteoporosis
6) Confidence 0.34 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.32 Pain Relevance 0
We also observed a significant down-regulation of SOX9 and RUNX2 in both of these mice (Figure 2L and 2M).
Regulation (regulation) of RUNX2
7) Confidence 0.34 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.29 Pain Relevance 0
The Smad2/3 and Smad1/5/8 balance controls the Runx2 function and terminal differentiation.


Regulation (controls) of Runx2
8) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.62 Pain Relevance 0.17

General Comments

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