INT142118

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 2.92
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx2) DNA binding (Runx2) transcription factor binding (Runx2)
cytoplasm (Runx2)
Runx2 (Mus musculus)
Pain Link Frequency Relevance Heat
Snapping jaw 5 50.00 Quite Low
Pain 8 13.84 Low Low
antagonist 3 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cleidocranial Dysplasia 124 99.12 Very High Very High Very High
Congenital Anomalies 16 97.84 Very High Very High Very High
Mixed Connective Tissue Disorder 8 94.56 High High
Temporomandibular Joint Syndrome 5 93.68 High High
Intellectual Impairment 8 93.60 High High
Osteoporosis 46 92.16 High High
Holoprosencephaly 8 80.60 Quite High
Learning Disorders 8 80.40 Quite High
Fracture Healing 36 75.00 Quite High
Joint Instability 12 70.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Atypical features seen in this patient cannot be explained by dysregulation of RUNX2 expression.
Regulation (dysregulation) of Gene_expression (expression) of RUNX2
1) Confidence 0.61 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.87 Pain Relevance 0
The expression of RUNX2 during development is regulated by at least two separate promoters.
Regulation (regulated) of Gene_expression (expression) of RUNX2
2) Confidence 0.61 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 1.05 Pain Relevance 0
Although the main regulation of RUNX2 expression is driven by two promoters, the promoter sequence alone does not seem to be sufficient for adequate control of the expression.
Regulation (regulation) of Gene_expression (expression) of RUNX2
3) Confidence 0.61 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.19 Pain Relevance 0
Expression of RUNX2 in these two mice, however, was regulated in the opposite manner (Figure 4N and 4O).
Regulation (regulated) of Gene_expression (Expression) of RUNX2
4) Confidence 0.46 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.49 Pain Relevance 0
We examined the significant alterations of the expression patterns of bone morphogenetic protein (BMP)-4, Runx2, and bone sialoprotein (BSP) after ovariectomy.
Spec (examined) Regulation (alterations) of Gene_expression (expression) of Runx2
5) Confidence 0.45 Published 2007 Journal Oral Dis Section Body Doc Link 17305626 Disease Relevance 0.09 Pain Relevance 0
For proper skeletal development and homeostasis, the expression of RUNX2 is tightly regulated during development in a strict temporal and spatial fashion.
Regulation (regulated) of Gene_expression (expression) of RUNX2
6) Confidence 0.27 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.23 Pain Relevance 0

General Comments

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