INT142120

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Context Info
Confidence 0.77
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 45
Total Number 47
Disease Relevance 15.76
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx2) DNA binding (Runx2) transcription factor binding (Runx2)
cytoplasm (Runx2)
Anatomy Link Frequency
regulatory T cells 4
stem cells 4
dentin 4
chondrocytes 2
osteoblast 2
Runx2 (Mus musculus)
Pain Link Frequency Relevance Heat
Snapping jaw 24 99.24 Very High Very High Very High
Pain 29 99.08 Very High Very High Very High
aspirin 42 98.76 Very High Very High Very High
Osteoarthritis 198 98.16 Very High Very High Very High
Mechanotransduction 11 93.56 High High
metalloproteinase 6 88.96 High High
dexamethasone 15 87.60 High High
cytokine 29 74.88 Quite High
Chronic pancreatitis 36 64.88 Quite High
Inflammation 31 53.04 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 319 100.00 Very High Very High Very High
Osteogenic Sarcomas 36 100.00 Very High Very High Very High
Holoprosencephaly 18 100.00 Very High Very High Very High
Cleidocranial Dysplasia 280 99.92 Very High Very High Very High
Adenocarcinoma 62 99.84 Very High Very High Very High
Temporomandibular Joint Syndrome 24 99.24 Very High Very High Very High
Sprains And Strains 27 99.00 Very High Very High Very High
Osteoarthritis 208 98.16 Very High Very High Very High
Congenital Anomalies 59 97.84 Very High Very High Very High
Systemic Lupus Erythematosus 257 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of RUNX2 during development is regulated by at least two separate promoters.
Gene_expression (expression) of RUNX2
1) Confidence 0.77 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 1.03 Pain Relevance 0
Atypical features seen in this patient cannot be explained by dysregulation of RUNX2 expression.
Gene_expression (expression) of RUNX2
2) Confidence 0.77 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.87 Pain Relevance 0
Although the main regulation of RUNX2 expression is driven by two promoters, the promoter sequence alone does not seem to be sufficient for adequate control of the expression.
Gene_expression (expression) of RUNX2
3) Confidence 0.77 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.18 Pain Relevance 0
Alteration of BMP-4 and Runx2 expression patterns in mouse temporomandibular joint after ovariectomy.
Gene_expression (expression) of Runx2 in temporomandibular joint associated with snapping jaw
4) Confidence 0.77 Published 2007 Journal Oral Dis Section Title Doc Link 17305626 Disease Relevance 0.47 Pain Relevance 0.45
In the ovariectomy group, the intensity of BMP-4 and Runx2 expression increased after ovariectomy.
Gene_expression (expression) of Runx2
5) Confidence 0.77 Published 2007 Journal Oral Dis Section Body Doc Link 17305626 Disease Relevance 0.08 Pain Relevance 0
Results: In the control group, BMP-4, Runx2, and BSP expressions showed no definite difference at any stage.
Gene_expression (expressions) of Runx2
6) Confidence 0.77 Published 2007 Journal Oral Dis Section Body Doc Link 17305626 Disease Relevance 0.09 Pain Relevance 0
We examined the significant alterations of the expression patterns of bone morphogenetic protein (BMP)-4, Runx2, and bone sialoprotein (BSP) after ovariectomy.
Gene_expression (expression) of Runx2
7) Confidence 0.77 Published 2007 Journal Oral Dis Section Body Doc Link 17305626 Disease Relevance 0.09 Pain Relevance 0
Our results suggest that overexpression of Runx2 might be a useful prognostic marker in osteosarcoma cases.


Gene_expression (overexpression) of Runx2
8) Confidence 0.71 Published 2009 Journal Tumori Section Body Doc Link 19688969 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: High expression of Runx2 was significantly related to tumor metastasis in osteosarcoma.
Gene_expression (expression) of Runx2
9) Confidence 0.71 Published 2009 Journal Tumori Section Body Doc Link 19688969 Disease Relevance 0.07 Pain Relevance 0
High expression of Runx2 indicated a trend toward a poor survival rate (P = 0.056).
Gene_expression (expression) of Runx2
10) Confidence 0.71 Published 2009 Journal Tumori Section Body Doc Link 19688969 Disease Relevance 0.08 Pain Relevance 0
Prognostic implication of immunohistochemical Runx2 expression in osteosarcoma.
Gene_expression (expression) of Runx2 associated with pain and osteogenic sarcomas
11) Confidence 0.71 Published 2009 Journal Tumori Section Title Doc Link 19688969 Disease Relevance 0.47 Pain Relevance 0.10
RESULTS: High expression of Runx2 was significantly related to metastasis (P = 0.015).
Gene_expression (expression) of Runx2
12) Confidence 0.71 Published 2009 Journal Tumori Section Body Doc Link 19688969 Disease Relevance 0.08 Pain Relevance 0
We studied the protein expression of Runx2, IHH, and Sox9 in osteosarcoma and correlated their expression with clinicopathological variables.
Gene_expression (expression) of Runx2 associated with osteogenic sarcomas
13) Confidence 0.71 Published 2009 Journal Tumori Section Abstract Doc Link 19688969 Disease Relevance 0.44 Pain Relevance 0
Expression of Sox9, Runx2, and Osterix was low, as was that of collagen II, collagen I, and aggrecan, thus altering the fibrocartilaginous nature of the condyle.
Gene_expression (Expression) of Runx2 in condyle
14) Confidence 0.71 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20200412 Disease Relevance 0.25 Pain Relevance 0.31
Bone marrow-derived stromal cells in culture, when exposed to SR, displayed a significant increase in the expression of the master gene, Runx2, as well as bone sialoprotein (BSP), and this was associated with a significant increase in the formation of CFU-obs.
Gene_expression (expression) of Runx2 in stromal cells
15) Confidence 0.68 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.21 Pain Relevance 0
We propose that our patient's CCD phenotype is caused by disruption of a regulatory element for the RUNX2 gene at the 6p21 breakpoint causing altered expression of the gene resulting in CCD.
Gene_expression (expression) of RUNX2 associated with cleidocranial dysplasia
16) Confidence 0.67 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.85 Pain Relevance 0
Fosmid clones G248P86676H4, G248P8418A1, and G248P86565D3 located immediately upstream of the RUNX2 gene produced hybridization signal on the normal and derivative chromosome 6 only, suggesting that the entire coding sequence of RUNX2 including its promoter remained intact on the der(6) chromosome and was not translocated (Fig. 4b).
Gene_expression (produced) of RUNX2
17) Confidence 0.67 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.13 Pain Relevance 0
For proper skeletal development and homeostasis, the expression of RUNX2 is tightly regulated during development in a strict temporal and spatial fashion.
Gene_expression (expression) of RUNX2
18) Confidence 0.60 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.23 Pain Relevance 0
Napierala et al. 2005 reported two patients with promoter sequence variants and hypothesized that promoter mutations affecting binding of transcription factors critical for RUNX2 expression might change the transcriptional activity of the gene.
Gene_expression (expression) of RUNX2
19) Confidence 0.60 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.18 Pain Relevance 0
The mouse RUNX2 gene also contains two separate promoters [Xiao et al., 1998] and, in osteoblasts, RUNX2 expression is driven by the distal bone-related promoter.
Gene_expression (expression) of RUNX2 in osteoblasts
20) Confidence 0.60 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.15 Pain Relevance 0

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