INT142121
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In the ovariectomy group, the intensity of BMP-4 and Runx2 expression increased after ovariectomy. | |||||||||||||||
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Transgenic mice expressing BMP4 in cartilage under the control of the Col11a2 promoter/enhancer sequences die at birth due to respiratory failure [58] while mice overexpressing human BMP4 under control of mouse Msx1 minimal promoter develop no visible abnormalities [33]. | |||||||||||||||
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The only exception has been mice that overexpress BMP4 under control of the neuron specific enolase promoter (Nse-BMP4). | |||||||||||||||
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Overexpression of BMP4 under the control of many different promoters does not lead to postnatal HO. | |||||||||||||||
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For example, HO does not develop after overexpression of BMP4 under control of either the keratin promoter (K14) [32] or the bovine cytokeratin IV promoter [56]. | |||||||||||||||
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Mice that overexpress BMP4 under the Nephrin promoter have interesting defects in glomerular capillary formation but not the HO phenotype [60]. | |||||||||||||||
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Transgenic mice overexpressing BMP4 under control of surfactant protein-C gene promoter die from abnormally formed lungs [57]. | |||||||||||||||
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A study by Kan et al[66] demonstrated experimentally that overexpression of BMP-4 via a particular gene promoter was able to induce a FOP-like phenotype. | |||||||||||||||
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General Comments
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