INT142121

Context Info Confidence 0.47 First Reported 2007 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 8 Disease Relevance 7.00 Pain Relevance 0.21

cell differentiation (Bmp4) anatomical structure formation involved in morphogenesis (Bmp4) extracellular space (Bmp4) growth (Bmp4) extracellular region (Bmp4) proteinaceous extracellular matrix (Bmp4)

Anatomy Link Frequency glomerular capillary 2 cartilage 2 neuron 2 lungs 2 Bmp4 (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 2 88.80 cINOD 42 68.92 cva 2 57.72 Snapping jaw 5 50.00 Inflammation 27 5.00 Spinal cord 12 5.00 rheumatoid arthritis 7 5.00 spinal inflammation 7 5.00 Central nervous system 6 5.00 alcohol 6 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 72 99.88 Respiratory Failure 6 99.58 Heterotopic Ossification 601 99.52 Congenital Anomalies 24 97.40 Calcification 19 97.20 Atherosclerosis 6 96.32 Disease 10 93.24 Fibrodysplasia Ossificans Progressiva 103 92.08 Temporomandibular Joint Syndrome 5 82.32 Gonadal Disease 1 65.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the ovariectomy group, the intensity of BMP-4 and Runx2 expression increased after ovariectomy.

Positive_regulation (increased) of Gene_expression (expression) of BMP-4

1) Confidence 0.47 Published 2007 Journal Oral Dis Section Body Doc Link 17305626 Disease Relevance 0.08 Pain Relevance 0

Transgenic mice expressing BMP4 in cartilage under the control of the Col11a2 promoter/enhancer sequences die at birth due to respiratory failure [58] while mice overexpressing human BMP4 under control of mouse Msx1 minimal promoter develop no visible abnormalities [33].

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of BMP4 in cartilage associated with targeted disruption, congenital anomalies and respiratory failure

2) Confidence 0.32 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 1.11 Pain Relevance 0

The only exception has been mice that overexpress BMP4 under control of the neuron specific enolase promoter (Nse-BMP4).

Positive_regulation (overexpress) of Gene_expression (overexpress) of BMP4 in neuron

3) Confidence 0.27 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 1.25 Pain Relevance 0

Overexpression of BMP4 under the control of many different promoters does not lead to postnatal HO.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of BMP4 associated with heterotopic ossification

4) Confidence 0.27 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.69 Pain Relevance 0

For example, HO does not develop after overexpression of BMP4 under control of either the keratin promoter (K14) [32] or the bovine cytokeratin IV promoter [56].

Positive_regulation (overexpression) of Gene_expression (overexpression) of BMP4 associated with heterotopic ossification

5) Confidence 0.27 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.77 Pain Relevance 0

Mice that overexpress BMP4 under the Nephrin promoter have interesting defects in glomerular capillary formation but not the HO phenotype [60].

Positive_regulation (overexpress) of Gene_expression (overexpress) of BMP4 in glomerular capillary associated with heterotopic ossification

6) Confidence 0.27 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 1.21 Pain Relevance 0

Transgenic mice overexpressing BMP4 under control of surfactant protein-C gene promoter die from abnormally formed lungs [57].

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of BMP4 in lungs associated with targeted disruption

7) Confidence 0.23 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.97 Pain Relevance 0

A study by Kan et al[66] demonstrated experimentally that overexpression of BMP-4 via a particular gene promoter was able to induce a FOP-like phenotype.

Positive_regulation (overexpression) of Gene_expression (overexpression) of BMP-4

8) Confidence 0.23 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2674414 Disease Relevance 0.92 Pain Relevance 0.21

General Comments

This test has worked.