INT142123

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Context Info
Confidence 0.64
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 4.81
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx2) DNA binding (Runx2) transcription factor binding (Runx2)
cytoplasm (Runx2)
Anatomy Link Frequency
regulatory T cells 12
osteoblast 4
dentin 4
stromal cells 2
Runx2 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 42 98.96 Very High Very High Very High
dexamethasone 12 93.20 High High
cytokine 12 75.56 Quite High
Chronic pancreatitis 18 54.16 Quite High
Snapping jaw 5 50.00 Quite Low
Inflammation 27 23.60 Low Low
Pain 7 10.00 Low Low
fibrosis 1 5.28 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Holoprosencephaly 6 100.00 Very High Very High Very High
Cleidocranial Dysplasia 93 99.92 Very High Very High Very High
Osteogenic Sarcomas 8 98.40 Very High Very High Very High
Osteoporosis 86 98.36 Very High Very High Very High
Cancer 21 97.52 Very High Very High Very High
Systemic Lupus Erythematosus 257 96.48 Very High Very High Very High
Pancreatic Cancer 29 94.84 High High
Adenocarcinoma 31 88.96 High High
Temporomandibular Joint Syndrome 5 81.92 Quite High
Intellectual Impairment 6 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that overexpression of Runx2 might be a useful prognostic marker in osteosarcoma cases.


Positive_regulation (overexpression) of Gene_expression (overexpression) of Runx2
1) Confidence 0.64 Published 2009 Journal Tumori Section Body Doc Link 19688969 Disease Relevance 0.07 Pain Relevance 0
Bone marrow-derived stromal cells in culture, when exposed to SR, displayed a significant increase in the expression of the master gene, Runx2, as well as bone sialoprotein (BSP), and this was associated with a significant increase in the formation of CFU-obs.
Positive_regulation (increase) of Gene_expression (expression) of Runx2 in stromal cells
2) Confidence 0.61 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.21 Pain Relevance 0
After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).
Positive_regulation (elevated) of Gene_expression (expression) of Runx2 in dentin
3) Confidence 0.51 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.04
In the ovariectomy group, the intensity of BMP-4 and Runx2 expression increased after ovariectomy.
Positive_regulation (increased) of Gene_expression (expression) of Runx2
4) Confidence 0.50 Published 2007 Journal Oral Dis Section Body Doc Link 17305626 Disease Relevance 0.08 Pain Relevance 0
Napierala et al. 2005 reported two patients with promoter sequence variants and hypothesized that promoter mutations affecting binding of transcription factors critical for RUNX2 expression might change the transcriptional activity of the gene.
Positive_regulation (critical) of Gene_expression (expression) of RUNX2
5) Confidence 0.46 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.18 Pain Relevance 0
The mouse RUNX2 gene also contains two separate promoters [Xiao et al., 1998] and, in osteoblasts, RUNX2 expression is driven by the distal bone-related promoter.
Positive_regulation (driven) of Gene_expression (expression) of RUNX2 in osteoblasts
6) Confidence 0.46 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.15 Pain Relevance 0
The authors proposed that the phenotype was due to two position effect mutations, one at each breakpoint, altering the expression of the SHH (holoprosencephaly) and RUNX2 (CCD) genes.
Positive_regulation (altering) of Gene_expression (expression) of RUNX2 associated with cleidocranial dysplasia and holoprosencephaly
7) Confidence 0.44 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.78 Pain Relevance 0
The underlying mechanisms of aspirin effect on bone metabolism appear to correlate with increased expression of certain osteogenic genes including Runx2, a master gene for osteogenic differentiation, ALP, and OCN (Fig. 3O).
Positive_regulation (increased) of Gene_expression (expression) of Runx2 associated with aspirin
8) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440798 Disease Relevance 0 Pain Relevance 0.43
2; Runx2: Runt related transcription factor 2; Th17: T helper 17; TRAP: telomeric repeat amplification protocol; Tregs: regulatory T cells; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling; SHED: Stem cells from human exfoliated deciduous teeth; SLE: systemic lupus erythematosus; sRANKL: soluble receptor activator for nuclear factor ?
Positive_regulation (transferase) of Gene_expression (transferase) of Runt related transcription factor 2 in regulatory T cells associated with systemic lupus erythematosus
9) Confidence 0.37 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.27 Pain Relevance 0
2; Runx2: Runt related transcription factor 2; Th17: T helper 17; TRAP: telomeric repeat amplification protocol; Tregs: regulatory T cells; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling; SHED: Stem cells from human exfoliated deciduous teeth; SLE: systemic lupus erythematosus; sRANKL: soluble receptor activator for nuclear factor ?
Positive_regulation (regulatory T cells) of Gene_expression (transferase) of Runx2 in regulatory T cells associated with systemic lupus erythematosus
10) Confidence 0.37 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.27 Pain Relevance 0
2; Runx2: Runt related transcription factor 2; Th17: T helper 17; TRAP: telomeric repeat amplification protocol; Tregs: regulatory T cells; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling; SHED: Stem cells from human exfoliated deciduous teeth; SLE: systemic lupus erythematosus; sRANKL: soluble receptor activator for nuclear factor ?
Positive_regulation (regulatory T cells) of Gene_expression (transferase) of Runt related transcription factor 2 in regulatory T cells associated with systemic lupus erythematosus
11) Confidence 0.37 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.27 Pain Relevance 0
2; Runx2: Runt related transcription factor 2; Th17: T helper 17; TRAP: telomeric repeat amplification protocol; Tregs: regulatory T cells; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling; SHED: Stem cells from human exfoliated deciduous teeth; SLE: systemic lupus erythematosus; sRANKL: soluble receptor activator for nuclear factor ?
Positive_regulation (mediated) of Gene_expression (transferase) of Runt related transcription factor 2 in regulatory T cells associated with systemic lupus erythematosus
12) Confidence 0.37 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.27 Pain Relevance 0
2; Runx2: Runt related transcription factor 2; Th17: T helper 17; TRAP: telomeric repeat amplification protocol; Tregs: regulatory T cells; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling; SHED: Stem cells from human exfoliated deciduous teeth; SLE: systemic lupus erythematosus; sRANKL: soluble receptor activator for nuclear factor ?
Positive_regulation (mediated) of Gene_expression (transferase) of Runx2 in regulatory T cells associated with systemic lupus erythematosus
13) Confidence 0.37 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.27 Pain Relevance 0
2; Runx2: Runt related transcription factor 2; Th17: T helper 17; TRAP: telomeric repeat amplification protocol; Tregs: regulatory T cells; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling; SHED: Stem cells from human exfoliated deciduous teeth; SLE: systemic lupus erythematosus; sRANKL: soluble receptor activator for nuclear factor ?
Positive_regulation (transferase) of Gene_expression (transferase) of Runx2 in regulatory T cells associated with systemic lupus erythematosus
14) Confidence 0.37 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.27 Pain Relevance 0
After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).
Positive_regulation (increased) of Gene_expression (expression) of Runt related transcription factor 2 in dentin
15) Confidence 0.37 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.05
The transcription of BGLAP is dependent on the expression of runx2 transcription factor, which binds to an osteoblast-specific cis-acting element in the promoter of BGLAP [34].
Positive_regulation (dependent) of Gene_expression (expression) of runx2 in osteoblast associated with osteoporosis
16) Confidence 0.19 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.63 Pain Relevance 0.12
Both PTSCs and ATSCs in osteogenic medium expressed significantly higher levels of Runx2 compared to the same cells in control medium (Figure 3A, B, columns 7 and 8).


Positive_regulation (levels) of Gene_expression (expressed) of Runx2
17) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2822826 Disease Relevance 0.10 Pain Relevance 0

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