INT142128

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1) cytoplasm (Nrgn)
Nrgn (Mus musculus)
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 4 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
withdrawal 2 98.00 Very High Very High Very High
narcan 2 97.24 Very High Very High Very High
Morphine 2 93.32 High High
tolerance 1 72.56 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 3 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these data suggest that neurogranin plays an essential role in acute opioid dependence, possibly by affecting the CaMKII and CREB signaling pathway.
neurogranin Regulation (affecting) of CREB associated with addiction and opioid
1) Confidence 0.38 Published 2007 Journal Brain Res. Section Abstract Doc Link 17306231 Disease Relevance 0.25 Pain Relevance 0.89

General Comments

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