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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.82
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Erbb3) extracellular space (Erbb3) nucleus (Erbb3)
kinase activity (Erbb3)
Anatomy Link Frequency
radial 1
neurons 1
Erbb3 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 5 86.00 High High
addiction 1 82.36 Quite High
tetrodotoxin 1 80.80 Quite High
GABAergic 2 75.00 Quite High
imagery 3 62.72 Quite High
antagonist 14 15.92 Low Low
cerebral cortex 5 5.00 Very Low Very Low Very Low
Somatosensory cortex 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
positron emission tomography 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 10 89.68 High High
Hyperplasia 1 86.60 High High
Leukemia 1 76.08 Quite High
Cancer 80 70.92 Quite High
Carcinoma 8 67.92 Quite High
Prostate Cancer 4 64.80 Quite High
Adhesions 22 60.88 Quite High
Severe Combined Immunodeficiency 2 57.04 Quite High
Stomach Cancer 1 54.92 Quite High
Adenocarcinoma 4 48.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of BDNF were mediated by receptor tyrosine kinase B (TrkB) and mitogen-activated protein kinase kinase (MEK) activation since culturing neurons with either (9S,10R,12R)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'- kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester (K252a) or 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one (PD98059) blocked the augmentation in synaptic activity induced by the neurotrophin.
Positive_regulation (activation) of receptor tyrosine kinase B in neurons
1) Confidence 0.27 Published 2007 Journal Neuroscience Section Abstract Doc Link 17306467 Disease Relevance 0 Pain Relevance 0.30
4 can regulate the expression of ErBB-3 at the level of protein translation, resulting in a significant induction of ErBB-2/ErBB-3 heterodimerization and consequent activation of PI3K (Folgiero et al. 2007; Liu et al. 2007).
Positive_regulation (induction) of ErBB-3
2) Confidence 0.13 Published 2008 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2746574 Disease Relevance 0.82 Pain Relevance 0
Together, these results indicate that NRG1 via activation of erbB3/erbB4 receptors and Pi3K induces a realignment of vimentin+ radial glia (see also Figure 8).

Positive_regulation (activation) of erbB3 in radial
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

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