INT142162

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 21.90
Pain Relevance 4.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
blood 1
capillary 1
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 173 100.00 Very High Very High Very High
cytokine 583 99.98 Very High Very High Very High
Inflammation 788 99.92 Very High Very High Very High
Crohn's disease 154 99.56 Very High Very High Very High
rheumatoid arthritis 66 98.52 Very High Very High Very High
dexamethasone 18 95.92 Very High Very High Very High
Inflammatory response 63 95.84 Very High Very High Very High
Osteoarthritis 37 95.24 Very High Very High Very High
cINOD 31 92.40 High High
corticosteroid 38 91.68 High High
Disease Link Frequency Relevance Heat
Cancer 114 100.00 Very High Very High Very High
Atherosclerosis 83 100.00 Very High Very High Very High
Necrosis 38 100.00 Very High Very High Very High
Myocardial Infarction 77 99.98 Very High Very High Very High
INFLAMMATION 910 99.92 Very High Very High Very High
Infection 133 99.90 Very High Very High Very High
Alagille Syndrome 23 99.80 Very High Very High Very High
Disease 587 99.56 Very High Very High Very High
Skin Cancer 61 99.44 Very High Very High Very High
Asthma 798 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The risk of MI associated with increased IL-10 was not significantly elevated after adjustment for the risk indicators in model 1 (table 2).
IL-10 Binding (associated) of associated with myocardial infarction
1) Confidence 0.37 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.81 Pain Relevance 0
Additional adjustment for CRP and IL-6 (model 2) changed the mortality risk associated with high IL-10 to a non-significant level (adjusted odds ratio, 1.7; 95% confidence interval, 0.8 to 3.6) (p?
IL-10 Binding (associated) of
2) Confidence 0.37 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.77 Pain Relevance 0
Association of the IL-10 1170 polymorphism with the acute coronary syndrome and premature myocardial infarction
IL-10 Binding (Association) of associated with acute coronary syndrome and myocardial infarction
3) Confidence 0.37 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.78 Pain Relevance 0
The polymorphisms IL6 G-174C, IL8 T-251A, PPARgamma2 Pro(12)Ala, IL1beta T-31C, and IL10 C-592A were not associated with risk of BCC.
IL10 Binding (associated) of associated with skin cancer
4) Confidence 0.36 Published 2007 Journal Mutat. Res. Section Abstract Doc Link 17307204 Disease Relevance 0.88 Pain Relevance 0.36
, interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumour necrosis factor-alpha (TNF-?)
interleukin-10 Binding (interleukin-6) of associated with necrosis and cancer
5) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766003 Disease Relevance 0.20 Pain Relevance 0.08
In humans, on the other hand, Courtin et al. (2006) have associated two SNPs (IL10–592 C/A and TNF–308 G/A) with the development of African trypanosomiasis whereby the IL10?
IL10 Binding (associated) of associated with african trypanosomiasis
6) Confidence 0.35 Published 2008 Journal Mamm Genome Section Body Doc Link PMC2323435 Disease Relevance 0.81 Pain Relevance 0
Additionally, we included rs1800872 of IL10 (5' UTR) that lies within the putative STAT 3 binding site and has been associated with IL-10 expression [21,22].
IL10 Binding (associated) of
7) Confidence 0.32 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2648955 Disease Relevance 0.05 Pain Relevance 0
Several studies have analyzed the association of IL-10 or TNF?
IL-10 Spec (analyzed) Binding (association) of
8) Confidence 0.30 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526590 Disease Relevance 0.49 Pain Relevance 0.27
However, the ratio of IL10/TNF?
IL10 Binding (ratio) of
9) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 1.06 Pain Relevance 0.51
The ratio between IL10 and TNF?
IL10 Binding (ratio) of
10) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.51 Pain Relevance 0.30
Interestingly, the IL10/TNF?
IL10 Binding (Interestingly) of
11) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.64 Pain Relevance 0.30
IL10:rs1800872 and IL10RA:rs3135932 have been shown to decrease IL10 signaling by decreasing serum levels and altering IL10-IL10RA interactions, respectively [26], [27].
IL10 Binding (interactions) of
12) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.77 Pain Relevance 0.19
This diversity of responses indicates that downstream events following IL-10 binding may vary depending on the cell target phenotype and on the environment of that cell, thus making the role of IL-10 in OA pathogenesis more intriguing and difficult to understand.
IL-10 Binding (binding) of associated with osteoarthritis
13) Confidence 0.27 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.35 Pain Relevance 0.18
IL10 is recognized as a regulatory (anti-inflammatory) cytokine and can act on multiple cell types to regulate immune and inflammatory responses [15].
IL10 Binding (recognized) of associated with inflammatory response, inflammation and cytokine
14) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.02 Pain Relevance 0.33
Several independent groups have found that IL-10 and TGF-?
IL-10 Binding (found) of
15) Confidence 0.23 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868866 Disease Relevance 1.93 Pain Relevance 0.19
Past and chronic infections are associated with a higher level of COX-2 and IL-10 mRNA
IL-10 Binding (associated) of associated with infection
16) Confidence 0.23 Published 2010 Journal Malar J Section Body Doc Link PMC2831904 Disease Relevance 1.68 Pain Relevance 0
/low IL-10 have the highest risk factor for developing SLE and producing antibodies to the SSa antigen [10], suggesting that interactions between IL-10 and TNF?
IL-10 Binding (interactions) of associated with systemic lupus erythematosus
17) Confidence 0.23 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526590 Disease Relevance 0.67 Pain Relevance 0.18
Therefore, using logistic regression modeling, we evaluated the influence of single and combined IL-10 and TNF?
IL-10 Binding (combined) of
18) Confidence 0.23 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526590 Disease Relevance 0.15 Pain Relevance 0.14
Combined IL-10 and TNF?
IL-10 Binding (Combined) of
19) Confidence 0.23 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526590 Disease Relevance 0.39 Pain Relevance 0.12
The scatter plot of log signal intensities from the HV pool (horizontal) and patient TA8 (vertical) show that the signal intensities of IL-4 and IL-10 are considerably lower than that of DEFA3.
IL-10 Binding (intensities) of
20) Confidence 0.19 Published 2010 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2993541 Disease Relevance 0.16 Pain Relevance 0

General Comments

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