INT142174

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 11.86
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
skin 4
intestinal cell 2
thyroid 2
liver 2
muscle 2
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 45 100.00 Very High Very High Very High
qutenza 21 100.00 Very High Very High Very High
Somatostatin 91 99.04 Very High Very High Very High
Inflammation 41 97.32 Very High Very High Very High
Calcitonin gene-related peptide 12 97.20 Very High Very High Very High
antagonist 18 95.96 Very High Very High Very High
COX-2 inhibitor 3 92.72 High High
dorsal root ganglion 3 72.92 Quite High
Root ganglion neuron 1 66.36 Quite High
Pain 16 66.32 Quite High
Disease Link Frequency Relevance Heat
Stress 102 100.00 Very High Very High Very High
Sprains And Strains 201 99.64 Very High Very High Very High
Disease 67 99.42 Very High Very High Very High
Alopecia 8 99.36 Very High Very High Very High
Hypertrophy 16 98.92 Very High Very High Very High
Aging 405 98.76 Very High Very High Very High
Wound Healing 34 97.72 Very High Very High Very High
Injury 102 97.68 Very High Very High Very High
INFLAMMATION 44 97.32 Very High Very High Very High
Fibrosis 3 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although it is well known that growth hormone (GH) increases serum IGF-I levels by stimulating the hepatic production, little is known about the mechanism by which local production of IGF-I in individual tissues is regulated.
Regulation (regulated) of Gene_expression (production) of IGF-I
1) Confidence 0.60 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.35 Pain Relevance 0.34
On the other hand, results of this analysis suggest that dwarf mutations have a much larger and more consistent effect on IGF-I expression than CR treatments (as well as potential CR mimetic compounds).
Regulation (effect) of Gene_expression (expression) of IGF-I
2) Confidence 0.59 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.26 Pain Relevance 0
Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans.
Regulation (Effect) of Gene_expression (production) of insulin-like growth factor-I in hair associated with alopecia
3) Confidence 0.59 Published 2008 Journal Growth Horm. IGF Res. Section Title Doc Link 18321745 Disease Relevance 0.39 Pain Relevance 0.36
Eight days after cauterization, there was a slight change in IGF-1 expression in the untreated mice, compared to a 3.6-fold increase in the bevacizumab-treated group.
Regulation (change) of Gene_expression (expression) of IGF-1
4) Confidence 0.51 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 0.42 Pain Relevance 0.07
Effects of topical application of alpha-D-glucosylglycerol on dermal levels of insulin-like growth factor-i in mice and on facial skin elasticity in humans.
Regulation (Effects) of Gene_expression (levels) of insulin-like growth factor-i in skin associated with qutenza
5) Confidence 0.45 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Title Doc Link 20378988 Disease Relevance 0.27 Pain Relevance 0.50
Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans.
Regulation (Effect) of Gene_expression (levels) of insulin-like growth factor-I in skin associated with qutenza
6) Confidence 0.44 Published 2007 Journal Growth Horm. IGF Res. Section Title Doc Link 17307377 Disease Relevance 0 Pain Relevance 1.03
Mevalonate did not abolish the effect of simvastatin on IGF-1Rbeta expression.
Regulation (effect) of Gene_expression (expression) of IGF
7) Confidence 0.44 Published 2007 Journal J Toxicol Sci Section Abstract Doc Link 17327694 Disease Relevance 0.22 Pain Relevance 0.05
Identification of genes affected by GH and IGF-I suppression is an important step towards understanding how this axis impacts longevity.
Regulation (affected) of Gene_expression (suppression) of IGF-I associated with aging
8) Confidence 0.43 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.82 Pain Relevance 0
This suggests that a relatively small number of genes may be specifically affected by IGF-I suppression in mouse liver.
Spec (may) Regulation (affected) of Gene_expression (suppression) of IGF-I in liver
9) Confidence 0.43 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0 Pain Relevance 0
Measurement of serum IGF-I levels by enzyme-linked immunosorbent assay (ELISA)
Regulation (Measurement) of Gene_expression (levels) of IGF-I
10) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0 Pain Relevance 0
Expression of insulin-like growth factor-1 and phosphorylation of Akt, mammalian target of rapamycin, and p70S6K were increased following synergist ablation, but were not affected by NS-398.
Neg (not) Regulation (affected) of Gene_expression (Expression) of insulin-like growth factor-1
11) Confidence 0.30 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19176887 Disease Relevance 0.77 Pain Relevance 0.25
Under somatostatin analog mono-treatment all patients had elevated IGF-I levels, but after combined treatment with a median weekly dose of 60 mg pegvisomant 95% of the patients had normalized their IGF-I levels.
Regulation (normalized) of Gene_expression (levels) of IGF-I associated with somatostatin
12) Confidence 0.28 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0 Pain Relevance 0.12
Plasma thyroxin (T4) levels, controlled by pituitary thyroid-stimulating hormone (TSH) were unaffected in females (bIGF1RKO+/?
Neg (unaffected) Regulation (unaffected) of Gene_expression (females) of bIGF1RKO in thyroid
13) Confidence 0.28 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.07 Pain Relevance 0
SRIH was indeed above control concentrations in the adult bIGF1RKO+/?
Regulation (adult) of Gene_expression (/) of bIGF1RKO associated with somatostatin
14) Confidence 0.28 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0 Pain Relevance 0.25
Identification of microRNAs differentially regulated during IGF-1 stimulated crypt cell proliferation
Regulation (regulated) of Gene_expression (proliferation) of IGF-1 in crypt cell
15) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0 Pain Relevance 0
miR-103 is directly involved in IGF-1 stimulated mouse intestinal cell proliferation
Regulation (involved) of Gene_expression (proliferation) of IGF-1 in intestinal cell
16) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0 Pain Relevance 0
IGF-I expression was far more sensitive to the dwarf mutations than any of the dietary treatments examined, including CR (see Fig. 1).
Regulation (sensitive) of Gene_expression (expression) of IGF-I
17) Confidence 0.26 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0 Pain Relevance 0
All dwarf mutations had larger and more consistent effects on IGF-I expression than dietary treatments.
Regulation (effects) of Gene_expression (expression) of IGF-I
18) Confidence 0.26 Published 2007 Journal BMC Genomics Section Abstract Doc Link PMC2094713 Disease Relevance 0.63 Pain Relevance 0
Serum concentrations of IGFBP-3 are fairly constant throughout the day and are controlled by hGH and IGF-1 levels (43).
Regulation (controlled) of Gene_expression (levels) of IGF-1
19) Confidence 0.26 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063566 Disease Relevance 0 Pain Relevance 0
Although IGF1 gene expression in muscle is sensitive to testosterone depletion or administration in men [18], [29], no sex difference in plasma IGF-1 levels or muscle IGF1 gene expression has been observed [10].
Regulation (sensitive) of Gene_expression (expression) of IGF1 in muscle
20) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0 Pain Relevance 0

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