INT142177

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 12
Disease Relevance 3.57
Pain Relevance 5.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca, Igf1) extracellular region (Calca, Igf1) nucleus (Calca)
intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
sensory neurons 16
brain 8
Calca (Mus musculus)
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 117 100.00 Very High Very High Very High
qutenza 88 96.72 Very High Very High Very High
Hippocampus 16 86.48 High High
ischemia 5 53.28 Quite High
spinal dorsal horn 4 46.64 Quite Low
agonist 2 46.00 Quite Low
parabrachial 4 44.72 Quite Low
antagonist 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 25 99.16 Very High Very High Very High
Cognitive Disorder 16 95.12 Very High Very High Very High
Alopecia 5 93.84 High High
Neurodegenerative Disease 12 88.08 High High
Targeted Disruption 9 74.96 Quite High
Cv Unclassified Under Development 5 53.28 Quite High
Sprains And Strains 5 25.00 Low Low
Injury 5 5.00 Very Low Very Low Very Low
Growth Hormone Deficiency 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcitonin gene-related peptide (CGRP) increases the production of insulin-like growth factor-I (IGF-I) in the mouse brain.
CGRP Positive_regulation (increases) of Gene_expression (production) of IGF-I in brain associated with calcitonin gene-related peptide
1) Confidence 0.78 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.40 Pain Relevance 0.44
Calcitonin gene-related peptide (CGRP) increases the production of insulin-like growth factor-I (IGF-I) in the mouse brain.
Calcitonin gene-related peptide Positive_regulation (increases) of Gene_expression (production) of IGF-I in brain associated with calcitonin gene-related peptide
2) Confidence 0.78 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.40 Pain Relevance 0.44
Calcitonin gene-related peptide (CGRP) increases insulin-like growth factor-I (IGF-I) production in fetal rat osteoblasts in vitro, suggesting that stimulation of sensory neurons might increase IGF-I production, thereby preventing apoptosis.
Calcitonin gene-related peptide Positive_regulation (increases) of Gene_expression (production) of IGF-I in sensory neurons associated with apoptosis and calcitonin gene-related peptide
3) Confidence 0.78 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.32 Pain Relevance 0.46
Calcitonin gene-related peptide (CGRP) increases insulin-like growth factor-I (IGF-I) production in fetal rat osteoblasts in vitro, suggesting that stimulation of sensory neurons might increase IGF-I production, thereby preventing apoptosis.
CGRP Positive_regulation (increases) of Gene_expression (production) of IGF-I in sensory neurons associated with apoptosis and calcitonin gene-related peptide
4) Confidence 0.78 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.32 Pain Relevance 0.46
Capsaicin activates vanilloid receptor-1, thereby increasing the release of calcitonin gene-related peptide (CGRP) from sensory neurons, and CGRP has been shown to increase IGF-I production.
CGRP Positive_regulation (increase) of Gene_expression (production) of IGF-I in sensory neurons associated with calcitonin gene-related peptide
5) Confidence 0.69 Published 2007 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17569567 Disease Relevance 0.24 Pain Relevance 0.45
Calcitonin gene-related peptide (CGRP) increases the production of insulin-like growth factor-I (IGF-I) in the mouse brain.
CGRP Positive_regulation (increases) of Gene_expression (production) of insulin-like growth factor-I in brain associated with calcitonin gene-related peptide
6) Confidence 0.56 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.40 Pain Relevance 0.44
Calcitonin gene-related peptide (CGRP) increases the production of insulin-like growth factor-I (IGF-I) in the mouse brain.
Calcitonin gene-related peptide Positive_regulation (increases) of Gene_expression (production) of insulin-like growth factor-I in brain associated with calcitonin gene-related peptide
7) Confidence 0.56 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.40 Pain Relevance 0.44
Calcitonin gene-related peptide (CGRP) increases insulin-like growth factor-I (IGF-I) production in fetal rat osteoblasts in vitro, suggesting that stimulation of sensory neurons might increase IGF-I production, thereby preventing apoptosis.
Calcitonin gene-related peptide Positive_regulation (increases) of Gene_expression (production) of insulin-like growth factor-I in sensory neurons associated with apoptosis and calcitonin gene-related peptide
8) Confidence 0.56 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.32 Pain Relevance 0.46
Calcitonin gene-related peptide (CGRP) increases insulin-like growth factor-I (IGF-I) production in fetal rat osteoblasts in vitro, suggesting that stimulation of sensory neurons might increase IGF-I production, thereby preventing apoptosis.
CGRP Positive_regulation (increases) of Gene_expression (production) of insulin-like growth factor-I in sensory neurons associated with apoptosis and calcitonin gene-related peptide
9) Confidence 0.56 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.32 Pain Relevance 0.46
Calcitonin gene-related peptide (CGRP) increases insulin-like growth factor-I (IGF-I) production in fetal rat osteoblasts in vitro, suggesting that stimulation of sensory neurons might increase IGF-I production, thereby preventing apoptosis.
CGRP Spec (might) Positive_regulation (increase) of Gene_expression (production) of IGF-I in sensory neurons associated with apoptosis and calcitonin gene-related peptide
10) Confidence 0.56 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.45 Pain Relevance 0.52
Since CGRP increases production of insulin-like growth factor-I (IGF-I) in fetal osteoblasts in vitro, it is possible that sensory neuron activation by capsaicin increases production of IGF-I.
CGRP Positive_regulation (increases) of Gene_expression (production) of insulin-like growth factor-I in sensory neuron associated with qutenza and calcitonin gene-related peptide
11) Confidence 0.48 Published 2007 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17307377 Disease Relevance 0 Pain Relevance 0.57
Since CGRP increases production of insulin-like growth factor-I (IGF-I) in fetal osteoblasts in vitro, it is possible that sensory neuron activation by capsaicin increases production of IGF-I.
CGRP Positive_regulation (increases) of Gene_expression (production) of IGF-I in sensory neuron associated with qutenza and calcitonin gene-related peptide
12) Confidence 0.34 Published 2007 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17307377 Disease Relevance 0 Pain Relevance 0.57

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