INT142205

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
pituitary 6
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 12 99.98 Very High Very High Very High
agonist 4 99.78 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Through activation of pituitary alpha2-adrenoreceptors, NE or the alpha2-agonist clonidine reduced both basal and PACAP-induced GH release and GH mRNA expression.
Negative_regulation (reduced) of Transcription (expression) of GH in pituitary associated with agonist and clonidine
1) Confidence 0.16 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17311897 Disease Relevance 0 Pain Relevance 0.32
Since our recent studies have shown that PACAP can induce GH secretion in carp pituitary cells through cAMP/PKA- and Ca2+/calmodulin-dependent mechanisms, these results, taken together, suggest that alpha2-adrenergic stimulation in the carp pituitary may inhibit PACAP-induced GH release and GH gene transcription by blocking the AC/cAMP/PKA pathway and Ca2+ entry through L-type VSCC.
Negative_regulation (inhibit) of Transcription (transcription) of GH in pituitary
2) Confidence 0.16 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17311897 Disease Relevance 0 Pain Relevance 0.23
In parallel experiments, clonidine reduced GH primary transcript and GH promoter activity without affecting GH mRNA stability, and these inhibitory actions were mimicked by inhibiting adenylate cyclase (AC), blocking protein kinase A (PKA), removing extracellular Ca2+ in the culture medium, or inactivating L-type voltage-sensitive Ca2+ channels (VSCC).
Negative_regulation (reduced) of Transcription (transcript) of GH associated with clonidine
3) Confidence 0.16 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17311897 Disease Relevance 0 Pain Relevance 0.31
Since our recent studies have shown that PACAP can induce GH secretion in carp pituitary cells through cAMP/PKA- and Ca2+/calmodulin-dependent mechanisms, these results, taken together, suggest that alpha2-adrenergic stimulation in the carp pituitary may inhibit PACAP-induced GH release and GH gene transcription by blocking the AC/cAMP/PKA pathway and Ca2+ entry through L-type VSCC.
Negative_regulation (inhibit) of Transcription (transcription) of GH in pituitary
4) Confidence 0.16 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17311897 Disease Relevance 0 Pain Relevance 0.23

General Comments

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