INT142236

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2010
Negated 8
Speculated 2
Reported most in Body
Documents 13
Total Number 18
Disease Relevance 5.02
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
adipose tissue 4
brain 2
striatum 2
apoptotic cell 2
cortex 2
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 100.00 Very High Very High Very High
opioid receptor 2 100.00 Very High Very High Very High
antidepressant 20 99.84 Very High Very High Very High
Dopamine 5 99.36 Very High Very High Very High
Eae 89 99.20 Very High Very High Very High
tolerance 58 95.20 Very High Very High Very High
cytokine 24 91.92 High High
Opioid 1 88.44 High High
Hippocampus 13 86.88 High High
Anterior cingulate cortex 1 86.24 High High
Disease Link Frequency Relevance Heat
Obesity 33 99.96 Very High Very High Very High
Shock 92 99.40 Very High Very High Very High
Sprains And Strains 6 97.80 Very High Very High Very High
Targeted Disruption 363 97.60 Very High Very High Very High
Apoptosis 36 96.80 Very High Very High Very High
Hypoxia 58 96.10 Very High Very High Very High
Death 18 95.84 Very High Very High Very High
Impaired Glucose Tolerance 47 95.20 Very High Very High Very High
Diabetes Mellitus 58 89.80 High High
Hypertrophy 27 84.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we investigated the effects of As2O3 on the phosphorylation of Akt and its downstream signals, mTOR and p70s6k, during myogenic differentiation.
Spec (investigated) Regulation (effects) of Phosphorylation (phosphorylation) of Akt
1) Confidence 0.61 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0 Pain Relevance 0
Ethanol-induced AKT phosphorylation was blocked by the opioid receptor antagonist naltrexone but unaffected by blockade of dopamine D2 receptors via sulpiride.
Neg (unaffected) Regulation (unaffected) of Phosphorylation (phosphorylation) of AKT associated with dopamine, antagonist and opioid receptor
2) Confidence 0.60 Published 2010 Journal Addict Biol Section Abstract Doc Link 20456289 Disease Relevance 0 Pain Relevance 0.32
Effects of lithium on Akt and GSK3 phosphorylation may vary depending upon the brain region or the mouse strain.
Regulation (Effects) of Phosphorylation (phosphorylation) of Akt in brain associated with sprains and strains
3) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.42 Pain Relevance 0.04
Additionally, our results showing that LiCl (200 mg/kg i.p.) did not affect locomotor activity in WT mice (Figure 2c) may support the results of Akt and GSK3 phosphorylation in WT cortex.
Regulation (results) of Phosphorylation (phosphorylation) of Akt in cortex associated with eae
4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.25 Pain Relevance 0.08
On the other hand, in the present study we focused solely on the cortical changes of Akt and GSK3 phosphorylation.
Regulation (changes) of Phosphorylation (phosphorylation) of Akt
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.41 Pain Relevance 0.04
Some reports have shown that lithium affects both Akt and GSK3 phosphorylation in the striatum of WT animals [36].
Regulation (affects) of Phosphorylation (phosphorylation) of Akt in striatum
6) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.37 Pain Relevance 0.04
HS+MES extended the duration of Akt phosphorylation through the increase of Hsp72 expression in HepG2 cells
Regulation (through) of Phosphorylation (phosphorylation) of Akt associated with shock
7) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.33 Pain Relevance 0
However, the phosphorylation level of Akt, a key signal molecule mediating the metabolic actions of insulin, was not altered by reduction of ROS.
Neg (not) Regulation (altered) of Phosphorylation (phosphorylation) of Akt
8) Confidence 0.31 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.29 Pain Relevance 0.08
Probably because of the opposite changes of insulin signal at IRS-1 and IRS-2, Akt phosphorylation was not affected by reduction of ROS.
Neg (not) Regulation (affected) of Phosphorylation (phosphorylation) of Akt
9) Confidence 0.31 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.12 Pain Relevance 0
In contrast, we have not observed any modulation of the phosphorylation of TrkB Shc binding site, phosphorylation of mitogen-activated protein kinase or AKT by antidepressants.
Regulation (modulation) of Phosphorylation (phosphorylation) of AKT associated with antidepressant
10) Confidence 0.26 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.76
In addition, we observed only minimal if any changes in phosphorylation of Akt, another important downstream mediator of c-Met pathway.
Regulation (changes) of Phosphorylation (phosphorylation) of Akt
11) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.12 Pain Relevance 0
In adipose tissue, AKT phosphorylation at Thr 308 was unchanged by either treatment.
Neg (unchanged) Regulation (unchanged) of Phosphorylation (phosphorylation) of AKT in adipose tissue associated with obesity
12) Confidence 0.23 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.76 Pain Relevance 0.11
PKB-mediated phosphorylation of rhSp1 had no effect on DNA binding (data not shown), thereby suggesting that a downstream kinase(s) was potentially mediating the actions of PKB on Sp1/Sp3 binding.
Neg (no) Regulation (effect) of Phosphorylation (phosphorylation) of PKB-mediated
13) Confidence 0.21 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
The changes in ERK and Akt phosphorylation levels were also observed in white adipose tissues of UCP1-knockout mice fed the evodiamine diet.
Regulation (changes) of Phosphorylation (phosphorylation) of Akt in adipose tissues associated with targeted disruption
14) Confidence 0.21 Published 2008 Journal Endocrinology Section Abstract Doc Link 17884939 Disease Relevance 0.38 Pain Relevance 0.13
Although no significant change in the phosphorylation level of Akt was observed in association with SOD1 overexpression, the phosphorylation of Foxo1 was significantly augumented by the SOD1 overexpression (Fig. 4C).
Neg (no) Regulation (change) of Phosphorylation (phosphorylation) of Akt
15) Confidence 0.14 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.08 Pain Relevance 0.04
Probably because the reduced IRS-2 phosphorylation can counteract the increased IRS-1 phosphorylation, insulin-stimulated phosphorylation of Akt might not be eventually affected by overexpression of SOD1 (Fig. 4A).
Neg (not) Spec (might) Regulation (affected) of Phosphorylation (phosphorylation) of Akt
16) Confidence 0.14 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0 Pain Relevance 0.05
On the other hand, there was no change in phosphorylation of AKT by [6]-gingerol-treated BxPC-3 cells and thus failed to counteract the gingerol-induced apoptotic cell death.
Neg (no) Regulation (change) of Phosphorylation (phosphorylation) of AKT in apoptotic cell associated with apoptosis and death
17) Confidence 0.12 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 1.08 Pain Relevance 0
expression and activation can be promoted by non-hypoxic mechanisms likely to be active in hypertrophying hearts, including increased reactive oxygen species production, mechanical stretch-activated channels, and phosphatidylinositol 3-kinase (PI3-K)-dependent Akt phosphorylation [20].
Regulation (dependent) of Phosphorylation (phosphorylation) of Akt in hearts associated with hypoxia
18) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 0.40 Pain Relevance 0

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