INT142237

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Context Info
Confidence 0.82
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 18
Disease Relevance 2.24
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
kinase activity (Ntrk2)
Anatomy Link Frequency
Mouse 3
neurons 2
brain 2
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 209 99.80 Very High Very High Very High
fluoxetine 22 99.66 Very High Very High Very High
Hippocampus 84 98.16 Very High Very High Very High
agonist 204 94.36 High High
Eae 63 92.88 High High
Desipramine 10 86.16 High High
Anterior cingulate cortex 3 85.52 High High
depression 106 84.88 Quite High
monoamine 8 81.88 Quite High
Nerve growth factor 103 77.44 Quite High
Disease Link Frequency Relevance Heat
Death 57 93.36 High High
Adhesions 6 91.52 High High
Apoptosis 191 91.32 High High
Convulsion 24 91.20 High High
Neuroblastoma 23 90.36 High High
Middle Cerebral Artery Infarction 1 87.44 High High
Shock 70 85.64 High High
Depression 128 84.88 Quite High
Stroke 45 84.24 Quite High
Disease 107 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since trkB.T1 heterodimerization with trkB.FL inhibits trans-autophosphorylation of the trkB.FL kinase domain, studies support a model in which trkB.T1 functions to reduce BDNF signaling [17-22].
Phosphorylation (autophosphorylation) of trkB
1) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.61 Pain Relevance 0.18
In contrast, we have not observed any modulation of the phosphorylation of TrkB Shc binding site, phosphorylation of mitogen-activated protein kinase or AKT by antidepressants.
Phosphorylation (phosphorylation) of TrkB associated with antidepressant
2) Confidence 0.81 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.73
We have previously shown that the antidepressants imipramine and fluoxetine produce a rapid autophosphorylation of TrkB in the rodent brain.
Phosphorylation (autophosphorylation) of TrkB in brain associated with antidepressant and fluoxetine
3) Confidence 0.81 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.47
Conceivably, the robust GST-TrkB phosphorylation might result from the intramolecular reaction in the stabilized conformation by the 3 chemicals mentioned above.
Phosphorylation (phosphorylation) of TrkB
4) Confidence 0.81 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.12 Pain Relevance 0.06
TrkB was selectively phosphorylated in the brain 2 h after injection, and peaked at 4–8 h, so was the downstream effectors Akt and Erk1/2 activation (Figure 2E, left panels), suggesting that deoxygedunin can penetrate the brain-blood barrier and stimulate TrkB activation.
Phosphorylation (phosphorylated) of TrkB in brain
5) Confidence 0.81 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
Mouse monoclonal P-TrkB 817 antibody recognized both human and mouse TrkB phosphorylation in addition to rat TrkB (Figure S2C).
Phosphorylation (phosphorylation) of TrkB in Mouse
6) Confidence 0.81 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
In contrast, we have not observed any modulation of the phosphorylation of TrkB Shc binding site, phosphorylation of mitogen-activated protein kinase or AKT by antidepressants.
Phosphorylation (phosphorylation) of TrkB associated with antidepressant
7) Confidence 0.81 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.74
Pretreatment of K252a substantially blocked deoxygedunin-triggered TrkB activation in cortical neurons (Figure 2D), indicating that deoxygedunin can provoke TrkB autophosphorylation.
Phosphorylation (autophosphorylation) of TrkB in neurons
8) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.06 Pain Relevance 0
This occurs through antidepressant-mediated autophosphorylation of TrkB.
Phosphorylation (autophosphorylation) of TrkB associated with antidepressant
9) Confidence 0.78 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.31 Pain Relevance 0.52
TrkB-KD displayed negligible phosphorylation compared to wild-type TrkB (Figure 3D), indicating that TrkB phosphorylation by deoxygedunin is through the receptor autophosphorylation but not by any other tyrosine kinases.
Phosphorylation (phosphorylation) of TrkB
10) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.08 Pain Relevance 0
Deoxygedunin also elicited tyrosine phosphorylation in TrkB but not in TrkA or TrkC receptor in transfected HEK293 cells.
Phosphorylation (phosphorylation) of TrkB
11) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.07 Pain Relevance 0
TrkB-KD displayed negligible phosphorylation compared to wild-type TrkB (Figure 3D), indicating that TrkB phosphorylation by deoxygedunin is through the receptor autophosphorylation but not by any other tyrosine kinases.
Phosphorylation (phosphorylation) of TrkB
12) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.08 Pain Relevance 0
Mouse monoclonal P-TrkB 817 antibody recognized both human and mouse TrkB phosphorylation in addition to rat TrkB (Figure S2C).
Phosphorylation (phosphorylation) of TrkB in Mouse
13) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
The coprecipitated HA-TrkB was also prominently tyrosine phosphorylated (3rd panel).
Phosphorylation (phosphorylated) of TrkB
14) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.06 Pain Relevance 0
For example, complex oligosaccharide modification and brain-derived neurotrophic factor-induced phosphorylation of the neurotrophin receptor TrkB was severely affected in neurons lacking PS1 expression [93].
Phosphorylation (phosphorylation) of TrkB in neurons
15) Confidence 0.61 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.24 Pain Relevance 0
TrkB-KD displayed negligible phosphorylation compared to wild-type TrkB (Figure 3D), indicating that TrkB phosphorylation by deoxygedunin is through the receptor autophosphorylation but not by any other tyrosine kinases.
Phosphorylation (phosphorylation) of TrkB
16) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.08 Pain Relevance 0
Mouse monoclonal P-TrkB 817 antibody recognized both human and mouse TrkB phosphorylation in addition to rat TrkB (Figure S2C).
Phosphorylation (phosphorylation) of P-TrkB in Mouse
17) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
This compound binds TrkA, but not TrkB or TrkC, and causes receptor dimerization and phosphorylation.
Phosphorylation (phosphorylation) of TrkB
18) Confidence 0.28 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.54 Pain Relevance 0.12

General Comments

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