INT142240

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.54
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Atf6b) nucleus (Atf6b) intracellular (Atf6b)
DNA binding (Atf6b)
Anatomy Link Frequency
neuronal 6
Atf6b (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 1 100.00 Very High Very High Very High
Spinal cord 5 99.84 Very High Very High Very High
withdrawal 3 99.70 Very High Very High Very High
Morphine 11 99.22 Very High Very High Very High
antidepressant 12 98.30 Very High Very High Very High
spinal dorsal horn 1 96.12 Very High Very High Very High
Calcitonin gene-related peptide 10 96.06 Very High Very High Very High
addiction 4 93.60 High High
Hippocampus 4 93.60 High High
Anterior cingulate cortex 1 92.96 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 43 91.44 High High
Ganglion Cysts 1 91.12 High High
Drug Dependence 4 79.08 Quite High
Headache 2 71.72 Quite High
Nociception 1 70.28 Quite High
Pain 3 67.60 Quite High
Targeted Disruption 8 65.48 Quite High
Disease 1 47.04 Quite Low
Sprains And Strains 1 26.96 Quite Low
Congenital Anomalies 3 24.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic morphine exposure and withdrawal significantly increased phosphorylation of N-methyl-D-aspartate receptor subunit NR2B as well as the activated forms of extracellular signal-regulated kinase and the cAMP response element binding protein in SC.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of cAMP response element binding protein associated with nmda receptor, withdrawal, spinal cord and morphine
1) Confidence 0.49 Published 2009 Journal FASEB J. Section Abstract Doc Link 18772347 Disease Relevance 0.23 Pain Relevance 1.34
Furthermore, the results indicate that acute and long-term antidepressant treatments induce TrkB-mediated activation of phospholipase-Cgamma1 (PLCgamma1) and increase the phosphorylation of cAMP-related element binding protein, a major transcription factor mediating neuronal plasticity.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of cAMP-related element binding protein in neuronal associated with antidepressant
2) Confidence 0.49 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.70
CGRP activated Ca(2+)-calmodulin-dependent kinase II, which became localized to the perimembrane region and neuronal processes, a phenomenon already apparent after 30 min and accompanied by a parallel increase in cAMP-response element-binding protein (CREB) phosphorylation and nuclear translocation.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of cAMP-response element-binding protein in neuronal associated with calcitonin gene-related peptide
3) Confidence 0.35 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.43 Pain Relevance 0.61
Additionally, NAN-190 decreased and 8-OH-DPAT increased phosphorylated cAMP response element-binding protein (CREB) levels in WT mice but not in KO mice.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of cAMP response element-binding protein
4) Confidence 0.33 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20164327 Disease Relevance 0.60 Pain Relevance 0.35
In addition, GTS inhibited the increase of cAMP response element binding protein (CREB) phosphorylation.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of cAMP response element binding protein
5) Confidence 0.27 Published 2008 Journal Arch. Pharm. Res. Section Abstract Doc Link 18365685 Disease Relevance 0.08 Pain Relevance 0.64
CaMKIV activates several transcription factors such as ATF-1, MEF2D and NF-kappaB [4-6], and is a key regulator of neuronal gene expression that stimulates transcription through the phosphorylation of the cAMP response element binding protein (CREB) and activation of the CREB co-activator, CREB binding protein (CBP) [2,3,7].
Positive_regulation (activation) of Phosphorylation (phosphorylation) of cAMP response element binding protein in neuronal
6) Confidence 0.26 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.20 Pain Relevance 0.22

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