INT142241

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.87
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
kinase activity (Ntrk2)
Anatomy Link Frequency
blood 2
neurons 2
brains 2
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 94 99.98 Very High Very High Very High
monoamine 4 99.02 Very High Very High Very High
Serotonin 2 96.20 Very High Very High Very High
Hippocampus 50 94.28 High High
depression 79 92.40 High High
Eae 15 89.40 High High
fluoxetine 19 82.76 Quite High
Desipramine 10 82.28 Quite High
agonist 36 69.04 Quite High
Anterior cingulate cortex 1 68.44 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 38 93.36 High High
Depression 101 92.40 High High
Shock 16 90.96 High High
Targeted Disruption 26 83.28 Quite High
Injury 5 65.80 Quite High
Stroke 8 64.60 Quite High
Cv Unclassified Under Development 4 64.32 Quite High
Adhesions 1 61.76 Quite High
Anxiety Disorder 47 17.28 Low Low
Ganglion Cysts 16 11.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies suggest that the behavioral effect of antidepressants requires TrkB activation along with an increase in BDNF expression.
Positive_regulation (requires) of Positive_regulation (activation) of TrkB associated with antidepressant
1) Confidence 0.66 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.37 Pain Relevance 0.56
Finally, brain monoamines seem to be critical mediators of antidepressant-induced TrkB activation, as antidepressants reboxetine and citalopram do not produce TrkB activation in the brains of serotonin- or norepinephrine-depleted mice.
Positive_regulation (induced) of Positive_regulation (activation) of TrkB in brains associated with antidepressant, serotonin and monoamine
2) Confidence 0.46 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.73
The positive gedunin derivatives elicited TrkB activation in rat hippocampal neurons (Figure 2A).
Positive_regulation (elicited) of Positive_regulation (activation) of TrkB in neurons
3) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.41 Pain Relevance 0.03
Intraperitoneal injection of deoxygedunin (5 mg/kg) into mice triggers TrkB activation in mouse brain after 2 h and peaked at 4–8 h, indicating that this compound or its metabolites can pass brain blood barrier and has a fairly long effective duration.
Positive_regulation (triggers) of Positive_regulation (activation) of TrkB in blood
4) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.09 Pain Relevance 0.10

General Comments

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