INT142264

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 47
Total Number 49
Disease Relevance 26.35
Pain Relevance 6.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
brain 2
covering 1
macrophages 1
livers 1
aorta 1
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 223 100.00 Very High Very High Very High
Neuritis 168 100.00 Very High Very High Very High
addiction 21 100.00 Very High Very High Very High
Multiple sclerosis 169 99.66 Very High Very High Very High
dexamethasone 507 99.62 Very High Very High Very High
Thalamus 17 99.02 Very High Very High Very High
aspirin 78 98.70 Very High Very High Very High
Inflammatory response 33 97.44 Very High Very High Very High
Inflammation 462 95.28 Very High Very High Very High
withdrawal 55 93.20 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 860 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 168 100.00 Very High Very High Very High
Atherosclerotic Plaque 22 99.98 Very High Very High Very High
Targeted Disruption 845 99.96 Very High Very High Very High
Demyelinating Disease 144 99.66 Very High Very High Very High
Atherosclerosis 471 99.60 Very High Very High Very High
Necrosis 28 99.52 Very High Very High Very High
Adhesions 142 99.38 Very High Very High Very High
Hyperlipidemia 107 99.24 Very High Very High Very High
Cancer 42 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the antigen presenting function of antigen presenting cells (APCs) in adaptive immunity appears to increase in apoE-deficient mice, there still lacks direct evidence that apoE functions directly on antigen presentation process.
Spec (appears) Positive_regulation (increase) of apoE
1) Confidence 0.50 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.36 Pain Relevance 0.23
Shifting the Th1/Th2 to the Th1 direction is one mechanism underlying increased susceptibility to EAN in apoE-deficient mice.
Positive_regulation (increased) of apoE associated with neuritis
2) Confidence 0.50 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 1.13 Pain Relevance 0.91
However, because these results were only observed in ApoE(-/-) and not in wild-type animals, coxibs may increase the risk of thrombosis in patients with a predisposition for thrombotic complications.
Neg (not) Positive_regulation (observed) of ApoE associated with thrombosis
3) Confidence 0.49 Published 2007 Journal J. Mol. Med. Section Abstract Doc Link 17318614 Disease Relevance 0.59 Pain Relevance 0.07
However, when the apoE-EM complexes were generated by the incubation of apoE at concentrations of 0.1 and 1 ?
Positive_regulation (incubation) of apoE
4) Confidence 0.48 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0 Pain Relevance 0
This notion is confirmed by our experiments performed to determine the effect of apoE on EM-induced cholesterol release using the apoE-EM complex at various apoE concentrations on the EM surface, that is, with increasing number of apoE molecules associated with EM, not only apoE4-EM, but also apoE3-EM lose their ability to induce cholesterol release, suggesting that apoE associated with EM strongly inhibits EM-mediated cholesterol release.
Positive_regulation (using) of apoE
5) Confidence 0.48 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 1.08 Pain Relevance 0.03
Moreover, as we previously reported [10], apoE4-HDL contains number of apoE molecules per particle twofold that of apoE3; however, apoE4-HDL induced a very-weak cholesterol release, whereas apoE3-HDL induced a strong cholesterol release (Figs. 1A and 1B).
Positive_regulation (induced) of apoE associated with disorder of lipid metabolism
6) Confidence 0.48 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 1.27 Pain Relevance 0.04
We also found that the dimerization of apoE3 by disulfide bonds causes the apoE-isoform dependence of the apoE binding affinity to lipids.
Positive_regulation (dependence) of apoE-isoform associated with addiction
7) Confidence 0.48 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.65 Pain Relevance 0.05
Although there still lacks evidence that apoE isoforms contribute differently in maintaining BNB or BBB integrity, considering the preference of apoE isoforms binding to different lipoprotein and apoE receptors, it might be presumed that apoE isoforms might influence the recovery of GBS due to cholesterol transport difference in regeneration and remyelination [134, 135].
Positive_regulation (contribute) of apoE associated with syndrome
8) Confidence 0.47 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.87 Pain Relevance 0.14
Also of note is that apoE levels in the CNS vary during the estrous cycle and estrogen could increase ApoE levels [76, 167–169].
Positive_regulation (increase) of ApoE
9) Confidence 0.47 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.46 Pain Relevance 0.12
In addition to these direct effects on neurons, we have recently published that glia from TR APOE mice show apoE isoform-dependent innate immune activation following stimulation of CD14/TLR4 co-receptors with LPS [39,40].
Positive_regulation (activation) of apoE in neurons
10) Confidence 0.47 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.07 Pain Relevance 0.04
Maeda and colleagues have previously demonstrated that despite brain regional differences in apoE expression, there are no isoform-specific differences in levels of apoE in brain tissue from these TR APOE mice, even with elevated apoE2 plasma levels [45].
Positive_regulation (elevated) of apoE2 in brain
11) Confidence 0.47 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0 Pain Relevance 0.17
Soluble apoE receptors are generated by two mechanisms, i.e., proteolysis of transmembrane receptors and by expression of alternately spliced isoforms of the proteins.
Positive_regulation (generated) of apoE
12) Confidence 0.46 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0
After 9 days of asbestos exposure, which has previously been shown to be the time point of the maximum inflammatory response in lung after inhalation of chrysotile asbestos fibers (Haegens et al. 2007; Sabo-Attwood et al. 2005), MCP-1 in BALF remained elevated, with ApoE?
Positive_regulation (elevated) of ApoE in lung associated with inflammatory response
13) Confidence 0.45 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535625 Disease Relevance 0.70 Pain Relevance 0.24
in apoE-/-mice fed with a high-fat diet was increased at CT0, CT4 and CT8, compared to those of C57BL/6J or apoE-/-mice fed with regular chow (Fig. 7).
Positive_regulation (increased) of apoE in fat
14) Confidence 0.45 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2807425 Disease Relevance 0.63 Pain Relevance 0
Here we show that apoE3-HDL induces a strong cholesterol release, while apoE4-HDL induces a very weak release, and that this isoform-specific effect of apoE associated with lipid particle (HDL or EM) is due to the finding that (1) apoE4 has a higher affinity to lipid particles and thus a greater number of apoE4 molecules bind to lipid particles than apoE3, and (2) with increasing number of apoE molecules covering the surface of lipid particle, both apoE3 and apoE4 inhibit the lipid-particle-mediated cholesterol release.
Positive_regulation (increasing) of apoE in covering associated with disorder of lipid metabolism
15) Confidence 0.44 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.78 Pain Relevance 0
When an increasing number of apoE molecules were associated with EM, both apoE3-EM and apoE4-EM induced little cholesterol release.
Positive_regulation (increasing) of apoE
16) Confidence 0.44 Published 2007 Journal Mol Neurodegener Section Abstract Doc Link PMC1876452 Disease Relevance 0.48 Pain Relevance 0.03
This notion is confirmed by our experiments performed to determine the effect of apoE on EM-induced cholesterol release using the apoE-EM complex at various apoE concentrations on the EM surface, that is, with increasing number of apoE molecules associated with EM, not only apoE4-EM, but also apoE3-EM lose their ability to induce cholesterol release, suggesting that apoE associated with EM strongly inhibits EM-mediated cholesterol release.
Positive_regulation (increasing) of apoE
17) Confidence 0.44 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 1.05 Pain Relevance 0
Ongoing studies in our group have shown a preliminary result of an isotype-specific effect of apoE in EAN, with the most severe clinical course occurring on APOE ?
Positive_regulation (occurring) of APOE associated with neuritis
18) Confidence 0.44 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.52 Pain Relevance 0.48
The increased NO production was shown to be coupled with an increased arginine uptake in male APOE ?
Positive_regulation (increased) of APOE
19) Confidence 0.44 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.46 Pain Relevance 0.03
Activation of primary astrocytes from APOE TR mice with LPS led to genotype-dependent differences in cytokine secretion that were the greatest in APOE ?
Positive_regulation (greatest) of APOE in astrocytes associated with cytokine
20) Confidence 0.44 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.32 Pain Relevance 0.21

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