INT142265

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 9.52
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
brain 2
neurons 1
Schwann cells 1
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 10 100.00 Very High Very High Very High
COX2 1 99.92 Very High Very High Very High
COX-2 inhibitor 1 96.08 Very High Very High Very High
Inflammation 130 95.28 Very High Very High Very High
fibrosis 19 94.60 High High
addiction 9 93.16 High High
Kinase C 20 93.12 High High
metalloproteinase 71 92.96 High High
Peripheral nervous system 5 90.72 High High
Neuritis 24 90.08 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 362 100.00 Very High Very High Very High
Atherosclerosis 79 100.00 Very High Very High Very High
Hyperlipidemia 25 100.00 Very High Very High Very High
Alzheimer's Dementia 265 98.12 Very High Very High Very High
Targeted Disruption 366 97.72 Very High Very High Very High
Disease 793 97.48 Very High Very High Very High
Stress 121 96.92 Very High Very High Very High
INFLAMMATION 137 95.28 Very High Very High Very High
Fibrosis 21 94.60 High High
Cognitive Disorder 128 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both of these processes are important for regulation of soluble apoE receptors and functions of membrane bound apoE receptors.
Regulation (regulation) of apoE
1) Confidence 0.60 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.13 Pain Relevance 0.17
To elucidate the mechanism underlying the apoE-isoform-specific effect on cholesterol release mediated by apoE-HDL, we used a complex consisting of lipid emulsion (EM) and recombinant human apoE3 or apoE4, because one cannot modulate the number of apoE molecules associated with HDL, but one can modulate apoE number associated with EM.
Regulation (modulate) of apoE associated with disorder of lipid metabolism
2) Confidence 0.59 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.97 Pain Relevance 0.04
Duan et al. in our group, further revealed that the antigen presenting capacity of Schwann cells in apoE-deficient mice was enhanced, which might occur via down-regulation of intracellular IL-6 production.
Regulation (regulation) of apoE in Schwann cells
3) Confidence 0.45 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.64 Pain Relevance 0.63
ApoE targeted replacement mice (apoE-TR mice) express one of the three human isoforms under the control of endogenous murine APOE promoter sequences in a conformation and at physiological levels in a temporal and spatial pattern comparable to endogenous mouse apoE [108].
Regulation (control) of APOE
4) Confidence 0.44 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.32 Pain Relevance 0.24
One of the most profound implications of the production of soluble apoE receptors is the possible dominant negative effect on apoE receptor function.
Spec (possible) Regulation (effect) of apoE receptor
5) Confidence 0.44 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.05 Pain Relevance 0.03
The effects of COX-2 selective and non-selective NSAIDs on the initiation and progression of atherosclerosis in ApoE-/- mice.
Regulation (effects) of ApoE associated with atherosclerosis, cinod and cox2
6) Confidence 0.44 Published 2007 Journal J. Mol. Med. Section Title Doc Link 17318614 Disease Relevance 0.32 Pain Relevance 0.29
Standard signals were demonstrated to be linear in the range of apoE protein amounts from 0 to 2 ?
Regulation (range) of apoE
7) Confidence 0.43 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.09 Pain Relevance 0.04
Homozygous APOE2, APOE3 and APOE4 targeted replacement (TR) mice 'humanized' at apoE were developed by Dr.
Regulation (targeted) of APOE4
8) Confidence 0.27 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0 Pain Relevance 0.13
Prospective studies with galantamine in large samples of patients in Europe (Aerssens et al 2001) and in USA (Raskind et al 2000) showed no effect of APOE genotypes on drug efficacy, but a retrospective study with a small number of AD cases in Croatia showed the intriguing result of 71% responders to galantamine treatment among APOE-4 homozygotes (Babic et al 2004).
Neg (no) Regulation (effect) of APOE associated with disease
9) Confidence 0.27 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.40 Pain Relevance 0
The mechanisms and regulation of the processes generating soluble apoE receptors, mediating the actions of these receptors, and controlling the eventual clearance of the soluble receptors are just now being examined.
Spec (examined) Regulation (regulation) of apoE
10) Confidence 0.26 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.20 Pain Relevance 0
Thus, specific apoE receptor shedding may represent a novel mechanism for modulating individual apoE receptor-ligand interactions and overall apoE receptor function.


Regulation (modulating) of apoE receptor
11) Confidence 0.26 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0
Thus, specific apoE receptor shedding may represent a novel mechanism for modulating individual apoE receptor-ligand interactions and overall apoE receptor function.


Regulation (modulating) of apoE receptor
12) Confidence 0.26 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0
However, in light of the essential roles these receptors play in synaptic function, integration into numerous signal transduction pathways and their wide-range of their ligands, it is likely that this type of negative feedback would be necessary in modulating the activity of specific or multiple apoE receptor subtypes.
Regulation (modulating) of apoE receptor
13) Confidence 0.26 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0.03
Effect of apoE-emulsion complex on cholesterol release from cultured neurons
Regulation (Effect) of apoE in neurons
14) Confidence 0.26 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 1.43 Pain Relevance 0.05
levels in the brains of 15-month-old Tg2576 mice, without altering APP, BACE-1, A disintegrin and metallopeptidase 10 (ADAM-10), nicastrin, IDE, APOE, or neprilysin [186].
Regulation (altering) of APOE in brains
15) Confidence 0.24 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.48 Pain Relevance 0
Nonparametric Kendall tau correlation coefficients were derived for the relationships between lesion size and MCP-1 concentrations in ApoE?
Regulation (concentrations) of ApoE
16) Confidence 0.23 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535625 Disease Relevance 0.27 Pain Relevance 0.22
ApoE immunoreactivity was found in all of the thioflavin S positive amyloid cores in the Tg mice with one or two ApoE alleles [15].
Regulation (immunoreactivity) of ApoE associated with targeted disruption and alzheimer's dementia
17) Confidence 0.21 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.81 Pain Relevance 0
The direct effect of hypercholesterolaemia on ApoE levels in the brain leads to an accumulation of A?.
Regulation (effect) of ApoE in brain associated with hyperlipidemia
18) Confidence 0.19 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.55 Pain Relevance 0.08
However, the role of ApoE isoforms is complex with additional reports also implicating ApoE ?
Regulation (role) of ApoE
19) Confidence 0.15 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 1.28 Pain Relevance 0.03
Homozygous APOE2, APOE3 and APOE4 targeted replacement (TR) mice 'humanized' at apoE were developed by Dr.
Regulation (targeted) of APOE2
20) Confidence 0.12 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0 Pain Relevance 0.13

General Comments

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