INT142274

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.29
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TRPM2) transmembrane transport (TRPM2)
Anatomy Link Frequency
teeth 2
neural 2
granulocytes 1
TRPM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
pulpitis 5 99.92 Very High Very High Very High
Pain 5 99.76 Very High Very High Very High
hyperexcitability 5 97.12 Very High Very High Very High
antagonist 7 95.60 Very High Very High Very High
Inflammation 8 74.48 Quite High
fibrosis 1 8.16 Low Low
agonist 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
TRP channel 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulpitis 5 99.92 Very High Very High Very High
Pain 5 99.76 Very High Very High Very High
Necrosis 10 99.40 Very High Very High Very High
Stress 9 95.80 Very High Very High Very High
INFLAMMATION 11 74.48 Quite High
Toxicity 1 45.04 Quite Low
Pneumonia 1 39.84 Quite Low
Disease 5 13.52 Low Low
Pulmonary Disease 2 12.08 Low Low
Asthma 1 9.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, increased TRPM2 expression in symptomatic pulp was the result of increased immunoreactivity in fibroblasts, whereas neural expression of TRPM2 was absent.
Neg (absent) Gene_expression (expression) of TRPM2 in neural
1) Confidence 0.78 Published 2007 Journal J Endod Section Abstract Doc Link 17320705 Disease Relevance 0.43 Pain Relevance 0.26
We provide a possible mechanism explaining the association between TRPM2 channel expression with pain and necrosis.
Gene_expression (expression) of TRPM2 associated with pain and necrosis
2) Confidence 0.78 Published 2007 Journal J Endod Section Abstract Doc Link 17320705 Disease Relevance 0.44 Pain Relevance 0.27
Additionally, increased TRPM2 expression in symptomatic pulp was the result of increased immunoreactivity in fibroblasts, whereas neural expression of TRPM2 was absent.
Gene_expression (expression) of TRPM2 in neural
3) Confidence 0.78 Published 2007 Journal J Endod Section Abstract Doc Link 17320705 Disease Relevance 0.43 Pain Relevance 0.26
TRPM2 channel expression was significantly increased in pulp from clinically diagnosed symptomatic teeth compared with pulp from asymptomatic teeth.
Gene_expression (expression) of TRPM2 in teeth
4) Confidence 0.78 Published 2007 Journal J Endod Section Abstract Doc Link 17320705 Disease Relevance 0.42 Pain Relevance 0.25
We hypothesized that TRPM2 channel expression is upregulated in pulpal tissue of symptomatic teeth with signs of irreversible pulpitis.
Gene_expression (expression) of TRPM2 in teeth associated with pulpitis
5) Confidence 0.78 Published 2007 Journal J Endod Section Abstract Doc Link 17320705 Disease Relevance 0.41 Pain Relevance 0.23
In TRPM2-transfected HEK-293 cells, Ca2+ is increased rapidly by H2O2 stimulation, suggesting the possibility that oxidative stress mediates influx of Ca2+ through TRPM2 in granulocytes [177].
Gene_expression (transfected) of TRPM2 in granulocytes associated with stress
6) Confidence 0.32 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.17 Pain Relevance 0.04
In June 2007, landscape and vegetation transects were conducted in the core home ranges and 33 tree and 21 grass species were identified in the SSR and KNP home ranges respectively.
Gene_expression (identified) of KNP
7) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2587706 Disease Relevance 0 Pain Relevance 0

General Comments

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