INT142276

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.26
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TRPM2) transmembrane transport (TRPM2)
Anatomy Link Frequency
teeth 4
neural 2
TRPM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
pulpitis 3 99.92 Very High Very High Very High
hyperexcitability 3 97.12 Very High Very High Very High
Pain 3 81.92 Quite High
antagonist 3 78.00 Quite High
Disease Link Frequency Relevance Heat
Pulpitis 3 99.92 Very High Very High Very High
Necrosis 6 98.00 Very High Very High Very High
Stress 3 94.72 High High
Pain 3 81.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPM2 channel expression was significantly increased in pulp from clinically diagnosed symptomatic teeth compared with pulp from asymptomatic teeth.
Positive_regulation (increased) of Gene_expression (expression) of TRPM2 in teeth
1) Confidence 0.70 Published 2007 Journal J Endod Section Abstract Doc Link 17320705 Disease Relevance 0.42 Pain Relevance 0.25
Additionally, increased TRPM2 expression in symptomatic pulp was the result of increased immunoreactivity in fibroblasts, whereas neural expression of TRPM2 was absent.
Positive_regulation (increased) of Gene_expression (expression) of TRPM2 in neural
2) Confidence 0.70 Published 2007 Journal J Endod Section Abstract Doc Link 17320705 Disease Relevance 0.43 Pain Relevance 0.26
We hypothesized that TRPM2 channel expression is upregulated in pulpal tissue of symptomatic teeth with signs of irreversible pulpitis.
Positive_regulation (upregulated) of Gene_expression (expression) of TRPM2 in teeth associated with pulpitis
3) Confidence 0.70 Published 2007 Journal J Endod Section Abstract Doc Link 17320705 Disease Relevance 0.41 Pain Relevance 0.24

General Comments

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