INT142277

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.00
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TRPM2) transmembrane transport (TRPM2)
Anatomy Link Frequency
neutrophils 2
granulocytes 1
fibroblasts 1
TRPM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 1 100.00 Very High Very High Very High
hyperexcitability 2 96.40 Very High Very High Very High
TRP channel 10 95.36 Very High Very High Very High
cINOD 3 80.52 Quite High
pulpitis 2 77.28 Quite High
Inflammation 24 77.12 Quite High
Pain 2 59.24 Quite High
Inflammatory response 6 57.36 Quite High
antagonist 8 57.28 Quite High
agonist 15 21.04 Low Low
Disease Link Frequency Relevance Heat
Stress 10 98.36 Very High Very High Very High
Necrosis 4 95.16 Very High Very High Very High
INFLAMMATION 33 80.28 Quite High
Pulpitis 2 77.28 Quite High
Pain 2 59.24 Quite High
Targeted Disruption 9 57.84 Quite High
Toxicity 3 47.68 Quite Low
Pneumonia 3 42.48 Quite Low
Disease 15 24.72 Low Low
Pulmonary Disease 6 14.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPM2 immunoreactivity is increased in fibroblasts, but not nerves, of symptomatic human dental pulp.
Positive_regulation (increased) of TRPM2 in fibroblasts
1) Confidence 0.70 Published 2007 Journal J Endod Section Title Doc Link 17320705 Disease Relevance 0.36 Pain Relevance 0.21
TRPM2 channels, members of the melastatin subfamily, mediate calcium influx in response to oxidative stress but during pathological states facilitate hyperexcitability and cellular necrosis via calcium excitotoxicity.
Positive_regulation (mediate) of TRPM2 associated with stress, necrosis and hyperexcitability
2) Confidence 0.50 Published 2007 Journal J Endod Section Abstract Doc Link 17320705 Disease Relevance 0.27 Pain Relevance 0.13
In TRPM2-transfected HEK-293 cells, Ca2+ is increased rapidly by H2O2 stimulation, suggesting the possibility that oxidative stress mediates influx of Ca2+ through TRPM2 in granulocytes [177].
Positive_regulation (increased) of TRPM2 in granulocytes associated with stress
3) Confidence 0.37 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.17 Pain Relevance 0.04
Some of these mechanisms might be sufficiently unique to allow a specific targeting of neutrophils as observed in TRPM2 activation [189].


Positive_regulation (activation) of TRPM2 in neutrophils
4) Confidence 0.25 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.14 Pain Relevance 0.20
Patch-clamp experiments in neutrophils provided evidence for a channel activation of the TRP family TRPM2 by intracellular ADPr [87, 88].
Positive_regulation (activation) of TRPM2 in neutrophils
5) Confidence 0.25 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.06 Pain Relevance 0.03
Coexpression of CaM1234 abolished TRPC6 activation secondary to Gq protein-coupled receptor activation or diacylglycerol application [31], [32] and strongly decreased activation of the adenosine diphosphoribose-sensitive channel TRPM2 [33], [34].
Positive_regulation (activation) of TRPM2 associated with adenocard
6) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.10
This long time series has enabled us to report on the reciprocal importance of KNP and SSR to the elephant and its attendant herd and that since the fence between the two reserves was dropped, the elephants consistently rely upon KNP for summer grazing and SSR for winter grazing and water.
Positive_regulation (importance) of KNP
7) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2587706 Disease Relevance 0 Pain Relevance 0

General Comments

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