INT142286

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.70
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLG, Plat) extracellular space (PLG, Plat) extracellular region (PLG, Plat)
plasma membrane (PLG) cytoplasm (Plat)
Anatomy Link Frequency
brain 1
white matter 1
PLG (Homo sapiens)
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 3 99.36 Very High Very High Very High
Spinal cord 1 84.64 Quite High
COX2 1 58.44 Quite High
Inflammation 3 48.04 Quite Low
Central nervous system 9 40.48 Quite Low
ischemia 5 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 99.16 Very High Very High Very High
Periventricular Leukomalacia 3 93.04 High High
Cyst 3 86.32 High High
Stroke 27 52.00 Quite High
Hypoxia 1 25.68 Quite Low
Cancer 1 18.80 Low Low
Necrosis 1 18.32 Low Low
Middle Cerebral Artery Infarction 17 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to the PA/plasmin system, tPA interacts with other effectors such as low-density lipoprotein receptor-related protein (LRP) [60], [61] and latent platelet-derived growth factor-CC (PDGF-CC) [62], [63] which may subsequently influence the brain ECM remodeling and neurite outgrowth. tPA converts PDGF-CC to an active form PDGF-C, which is expressed in embryonic and adult mouse brain and contributes to brain remodeling and spinal cord development [64].
plasmin Binding (interacts) of tPA in brain associated with spinal cord
1) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.05 Pain Relevance 0.04
Role of tissue-plasminogen activator (t-PA) in a mouse model of neonatal white matter lesions: interaction with plasmin inhibitors and anti-inflammatory drugs.
plasmin Binding (interaction) of t-PA in white matter associated with inflammation and cinod
2) Confidence 0.42 Published 2007 Journal Neuroscience Section Title Doc Link 17321054 Disease Relevance 0.64 Pain Relevance 0.27

General Comments

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