INT142310

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 2.07
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn2)
Accn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 232 100.00 Very High Very High Very High
TRP channel 2 90.64 High High
Hyperalgesia 8 88.80 High High
Spinal cord 2 81.56 Quite High
addiction 12 81.36 Quite High
Hippocampus 24 78.80 Quite High
Pain 10 75.00 Quite High
GABAergic 12 69.08 Quite High
Cancer pain 2 57.92 Quite High
ischemia 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 97.16 Very High Very High Very High
Acidosis 16 85.68 High High
Hyperalgesia 8 77.20 Quite High
Pain 8 75.00 Quite High
Cancer 6 75.00 Quite High
Breast Cancer 2 62.68 Quite High
Cancer Pain 2 57.92 Quite High
Hypercalcemia 2 44.24 Quite Low
Osteoporosis 2 43.60 Quite Low
Metastasis 2 41.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of note, ZOL reduced the expression of ASIC1a and ASIC1b.
Negative_regulation (reduced) of Gene_expression (expression) of ASIC1a
1) Confidence 0.30 Published 2007 Journal J. Bone Miner. Metab. Section Abstract Doc Link 17323179 Disease Relevance 1.04 Pain Relevance 0.66
Of note, ZOL reduced the expression of ASIC1a and ASIC1b.
Negative_regulation (reduced) of Gene_expression (expression) of ASIC1b
2) Confidence 0.22 Published 2007 Journal J. Bone Miner. Metab. Section Abstract Doc Link 17323179 Disease Relevance 1.04 Pain Relevance 0.66
16 s) from desensitization, reminiscent of the prolonged recovery property of heterologously expressed ASIC1a homomers (?
Negative_regulation (reminiscent) of Gene_expression (expressed) of ASIC1a
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.50
First, the ASIC current in NG cells recovers slowly (??
Negative_regulation (recovers) of Gene_expression (current) of ASIC associated with asic
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.50
Bath-application of either PcTX1 (30 nM, Fig. 5A) or amiloride (100 µM) markedly inhibited the ASIC current (red trace, 32±7 pA, Fig. 5A bottom) as well as the [Ca2+]i transient (red trace, peak ?
Negative_regulation (red) of Gene_expression (current) of ASIC associated with asic
5) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.16
Hippocampal NG2 glia have ASIC1a immunoreactivity
Negative_regulation (Hippocampal) of Gene_expression (glia) of ASIC1a
6) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.16

General Comments

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