INT142324

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 10.80
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1)
plasma membrane (Ncf1) cytoplasm (Ncf1)
Anatomy Link Frequency
monocytes 1
Aorta 1
Ncf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 29 99.18 Very High Very High Very High
Inflammation 92 97.60 Very High Very High Very High
fibrosis 36 94.52 High High
metalloproteinase 17 88.04 High High
GABAergic 9 50.00 Quite Low
Morphine 7 50.00 Quite Low
Inflammatory stimuli 2 10.48 Low Low
midbrain 4 9.04 Low Low
ketamine 16 5.00 Very Low Very Low Very Low
anesthesia 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 1512 99.28 Very High Very High Very High
Obesity 2029 98.92 Very High Very High Very High
Stress 225 97.88 Very High Very High Very High
INFLAMMATION 111 97.60 Very High Very High Very High
Pulmonary Fibrosis 30 94.52 High High
Disease 93 87.52 High High
Metabolic Syndrome 36 83.44 Quite High
Lung Injury 1 82.64 Quite High
Death 62 71.52 Quite High
Disorder Of Lipid Metabolism 2 67.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aorta of mice treated with morphine expressed higher levels of p47phox (a major subunit of nicotinamide adenine dinucleotide phosphate oxidase).
Gene_expression (expressed) of p47phox in Aorta
1) Confidence 0.75 Published 2007 Journal Anesthesiology Section Body Doc Link 17325512 Disease Relevance 0 Pain Relevance 0
Protein expression p47phox was determined by Western blotting.
Gene_expression (expression) of p47phox
2) Confidence 0.59 Published 2007 Journal Anesthesiology Section Body Doc Link 17325512 Disease Relevance 0 Pain Relevance 0
We therefore examined the fibrogenic response to bleomycin administration in mice deficient for the p47phox subunit of NADPH-oxidase [15] and analyzed the variations in the MMP/TIMP balance during this process.


Gene_expression (deficient) of p47phox
3) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.48 Pain Relevance 0.24
production and upregulated
                   expression of p47phox NADPH oxidase
                   in both young and aging C57 or ob/ob mouse groups (Fig. 5).


Gene_expression (expression) of p47phox associated with aging and obesity
4) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.81 Pain Relevance 0
production and
                   upregulated expression of p47phox
                   NADPH oxidase without an additive effect of the two. 
Gene_expression (expression) of p47phox
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.74 Pain Relevance 0
production and
                               p47phox expression
                       without an additive effect of the two, with the exception of intracellular
                           Ca2+ rise. 
Gene_expression (expression) of p47phox
6) Confidence 0.30 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852499 Disease Relevance 0.89 Pain Relevance 0
production and
                           p47phox NADPH oxidase
                   expression in young but not aging ob/ob mice. 
Gene_expression (expression) of p47phox associated with aging and obesity
7) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.78 Pain Relevance 0
production and
                           p47phox NADPH oxidase
                   expression. 
Gene_expression (expression) of p47phox
8) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.86 Pain Relevance 0
production and NADPH oxidase
                           (p47phox subunit) expression
Gene_expression (production) of p47phox
9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.68 Pain Relevance 0
In contrast, ten minutes after LPS stimulation, we detected virtually all the p47phox clustered at the membrane (Fig. 5, panel III and IV).
Gene_expression (detected) of p47phox
10) Confidence 0.27 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0 Pain Relevance 0
Nox2 requires co-assembly with not only p22phox , but its p47phox and p67phox subunits for activity, whereas Nox4 has been shown to be active in the absence of p47phox and p67phox [29].
Neg (absence) Gene_expression (absence) of p47phox
11) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0
and expression of NADPH oxidase
                   (p47phox), the enzyme responsible
               for O2? 
Gene_expression (expression) of p47phox
12) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.70 Pain Relevance 0
production
                   NADPH oxidase (p47phox subunit)
                       [25] using DHE fluorescence and Western blot
                   analysis, respectively. 
Gene_expression (production) of p47phox
13) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.71 Pain Relevance 0
production and
                       p47phox expression in young but
               not aging ob/ob mice favors a role for NADPH oxidase-dependent
                   O2? 
Gene_expression (expression) of p47phox associated with aging and obesity
14) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.91 Pain Relevance 0
production and
                       p47phox expression,
               physiological levels of leptin effectively restored leptin deficiency-induced
               changes in the phosphorylation of Akt, eNOS, JNK, I?
Gene_expression (expression) of p47phox
15) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.73 Pain Relevance 0
producing enzyme NADPH oxidase
                   (p47phox subunit) [25], Akt,
               eNOS, AMP-activated kinase (AMPK) and the stress signaling molecules p38 MAP kinase,
               JNK, extracellular signaling regulated kinase (ERK) and NF?
Gene_expression (producing) of p47phox associated with stress
16) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.34 Pain Relevance 0
production and NADPH oxidase
                           (p47phox subunit) expression
Gene_expression (expression) of p47phox
17) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.66 Pain Relevance 0
-stimulation also results in a relative increase in mRNA transcripts for both p47phox and gp91phox and an increase in p47phox protein expression in monocytes primed with INF?
Gene_expression (expression) of p47phox in monocytes
18) Confidence 0.21 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.09 Pain Relevance 0.03
Additionally, recently published work has reported that palmitic acid and cytokines induce effects on insulin secretion and p47phox expression to a similar extent in both BRIN-BD11 cells and mouse islets [22].
Gene_expression (expression) of p47phox associated with cytokine
19) Confidence 0.07 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0 Pain Relevance 0.05
B, iNOS and NADPH oxidase subunit levels and a reduction in NO and ROS levels respectively, resulting in a corresponding increase in the GSH/GSSG ratio.
Gene_expression (levels) of oxidase subunit
20) Confidence 0.07 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0.41 Pain Relevance 0.08

General Comments

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