INT142324

Context Info Confidence 0.75 First Reported 2005 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 19 Total Number 20 Disease Relevance 10.80 Pain Relevance 0.41

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1) plasma membrane (Ncf1) cytoplasm (Ncf1)

Anatomy Link Frequency monocytes 1 Aorta 1 Ncf1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 29 99.18 Inflammation 92 97.60 fibrosis 36 94.52 metalloproteinase 17 88.04 GABAergic 9 50.00 Morphine 7 50.00 Inflammatory stimuli 2 10.48 midbrain 4 9.04 ketamine 16 5.00 anesthesia 16 5.00

Disease Link Frequency Relevance Heat Aging 1512 99.28 Obesity 2029 98.92 Stress 225 97.88 INFLAMMATION 111 97.60 Pulmonary Fibrosis 30 94.52 Disease 93 87.52 Metabolic Syndrome 36 83.44 Lung Injury 1 82.64 Death 62 71.52 Disorder Of Lipid Metabolism 2 67.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Aorta of mice treated with morphine expressed higher levels of p47phox (a major subunit of nicotinamide adenine dinucleotide phosphate oxidase).

Gene_expression (expressed) of p47phox in Aorta

1) Confidence 0.75 Published 2007 Journal Anesthesiology Section Body Doc Link 17325512 Disease Relevance 0 Pain Relevance 0

Protein expression p47phox was determined by Western blotting.

Gene_expression (expression) of p47phox

2) Confidence 0.59 Published 2007 Journal Anesthesiology Section Body Doc Link 17325512 Disease Relevance 0 Pain Relevance 0

We therefore examined the fibrogenic response to bleomycin administration in mice deficient for the p47phox subunit of NADPH-oxidase [15] and analyzed the variations in the MMP/TIMP balance during this process.

Gene_expression (deficient) of p47phox

3) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.48 Pain Relevance 0.24

production and upregulated expression of p47phox NADPH oxidase in both young and aging C57 or ob/ob mouse groups (Fig. 5).

Gene_expression (expression) of p47phox associated with aging and obesity

4) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.81 Pain Relevance 0

production and upregulated expression of p47phox NADPH oxidase without an additive effect of the two.

Gene_expression (expression) of p47phox

5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.74 Pain Relevance 0

production and p47phox expression without an additive effect of the two, with the exception of intracellular Ca2+ rise.

Gene_expression (expression) of p47phox

6) Confidence 0.30 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852499 Disease Relevance 0.89 Pain Relevance 0

production and p47phox NADPH oxidase expression in young but not aging ob/ob mice.

Gene_expression (expression) of p47phox associated with aging and obesity

7) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.78 Pain Relevance 0

production and p47phox NADPH oxidase expression.

Gene_expression (expression) of p47phox

8) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.86 Pain Relevance 0

production and NADPH oxidase (p47phox subunit) expression

Gene_expression (production) of p47phox

9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.68 Pain Relevance 0

In contrast, ten minutes after LPS stimulation, we detected virtually all the p47phox clustered at the membrane (Fig. 5, panel III and IV).

Gene_expression (detected) of p47phox

10) Confidence 0.27 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0 Pain Relevance 0

Nox2 requires co-assembly with not only p22phox , but its p47phox and p67phox subunits for activity, whereas Nox4 has been shown to be active in the absence of p47phox and p67phox [29].

Neg (absence) Gene_expression (absence) of p47phox

11) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0

and expression of NADPH oxidase (p47phox), the enzyme responsible for O2?

Gene_expression (expression) of p47phox

12) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.70 Pain Relevance 0

production NADPH oxidase (p47phox subunit) [25] using DHE fluorescence and Western blot analysis, respectively.

Gene_expression (production) of p47phox

13) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.71 Pain Relevance 0

production and p47phox expression in young but not aging ob/ob mice favors a role for NADPH oxidase-dependent O2?

Gene_expression (expression) of p47phox associated with aging and obesity

14) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.91 Pain Relevance 0

production and p47phox expression, physiological levels of leptin effectively restored leptin deficiency-induced changes in the phosphorylation of Akt, eNOS, JNK, I?

Gene_expression (expression) of p47phox

15) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.73 Pain Relevance 0

producing enzyme NADPH oxidase (p47phox subunit) [25], Akt, eNOS, AMP-activated kinase (AMPK) and the stress signaling molecules p38 MAP kinase, JNK, extracellular signaling regulated kinase (ERK) and NF?

Gene_expression (producing) of p47phox associated with stress

16) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.34 Pain Relevance 0

production and NADPH oxidase (p47phox subunit) expression

Gene_expression (expression) of p47phox

17) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.66 Pain Relevance 0

-stimulation also results in a relative increase in mRNA transcripts for both p47phox and gp91phox and an increase in p47phox protein expression in monocytes primed with INF?

Gene_expression (expression) of p47phox in monocytes

18) Confidence 0.21 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.09 Pain Relevance 0.03

Additionally, recently published work has reported that palmitic acid and cytokines induce effects on insulin secretion and p47phox expression to a similar extent in both BRIN-BD11 cells and mouse islets [22].

Gene_expression (expression) of p47phox associated with cytokine

19) Confidence 0.07 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0 Pain Relevance 0.05

B, iNOS and NADPH oxidase subunit levels and a reduction in NO and ROS levels respectively, resulting in a corresponding increase in the GSH/GSSG ratio.

Gene_expression (levels) of oxidase subunit

20) Confidence 0.07 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0.41 Pain Relevance 0.08

General Comments

This test has worked.