INT142340

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 6.44
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Chkb) cytoplasm (Chkb)
Anatomy Link Frequency
muscle 5
upper 1
Chkb (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 6 99.88 Very High Very High Very High
fibrosis 10 83.76 Quite High
Angina 2 80.80 Quite High
Action potential 5 73.92 Quite High
antagonist 5 48.84 Quite Low
corticosteroid 5 45.76 Quite Low
Osteoarthritis 10 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 3 100.00 Very High Very High Very High
Pain 6 99.88 Very High Very High Very High
Muscle Weakness 35 99.28 Very High Very High Very High
Muscle Disease 116 99.24 Very High Very High Very High
Myocardial Infarction 53 97.74 Very High Very High Very High
Osteochondrodysplasias 135 97.22 Very High Very High Very High
Chronic Disease 2 96.96 Very High Very High Very High
Fatigue 10 96.72 Very High Very High Very High
Necrosis 6 96.64 Very High Very High Very High
Frailty 15 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase occasionally cause myopathy characterized by weakness, pain, and elevated serum creatine phosphokinase (CK).
Positive_regulation (elevated) of CK associated with pain, disorders of creatine metabolism and muscle disease
1) Confidence 0.47 Published 2007 Journal J Toxicol Sci Section Abstract Doc Link 17327694 Disease Relevance 0.48 Pain Relevance 0.10
In an MED family with a COL9A3 mutation patients presented with proximal muscle weakness (despite predominantly distal skeletal changes) and mildly elevated levels of creatine kinase (CK; an indicator of muscle degeneration and myopathy).
Positive_regulation (elevated) of CK in muscle associated with osteochondrodysplasias, muscle disease and muscle weakness
2) Confidence 0.24 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2875749 Disease Relevance 1.02 Pain Relevance 0
They suffered from muscle weakness from 3 years of age and had mildly elevated CK levels; however a muscle biopsy was not performed at the time.
Positive_regulation (elevated) of CK in muscle associated with muscle weakness
3) Confidence 0.24 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2875749 Disease Relevance 0.85 Pain Relevance 0
Occurrence of AMI was confirmed in all patients by a 2-fold upper limit of normal (190 U/L) rise in creatine kinase (CK), with an increased level of CK-MB.
Positive_regulation (increased) of CK-MB in upper associated with myocardial infarction
4) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637972 Disease Relevance 0.65 Pain Relevance 0.08
In an MED family with a COL9A3 mutation patients presented with proximal muscle weakness (despite predominantly distal skeletal changes) and mildly elevated levels of creatine kinase (CK; an indicator of muscle degeneration and myopathy).
Positive_regulation (levels) of CK in muscle associated with osteochondrodysplasias, muscle disease and muscle weakness
5) Confidence 0.16 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2875749 Disease Relevance 1.01 Pain Relevance 0
Blood samples from the patients showed normal or mildly increased CK levels and their muscle biopsy showed increased number of basophilic fibers, fiber necrosis, and/or variability in fiber diameters.
Positive_regulation (increased) of CK in muscle associated with necrosis
6) Confidence 0.16 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2875749 Disease Relevance 0.98 Pain Relevance 0
However, their plasma creatine kinase (CK) level (an indicator of muscle degeneration) is usually normal or only mildly elevated [89].
Positive_regulation (elevated) of CK in muscle
7) Confidence 0.16 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2875749 Disease Relevance 1.45 Pain Relevance 0.20

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