INT142341

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 2.44
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
sensory neurons 2
liver 2
fat 2
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 27 99.98 Very High Very High Very High
qutenza 16 99.98 Very High Very High Very High
ischemia 2 84.80 Quite High
Pain 14 59.36 Quite High
Neurobehavioral 12 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Pain threshold 4 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 19 98.24 Very High Very High Very High
Apoptosis 11 97.56 Very High Very High Very High
Cv Unclassified Under Development 2 84.80 Quite High
Hyperplasia 1 84.56 Quite High
Injury 3 84.00 Quite High
Disorders Of Creatine Metabolism 6 71.32 Quite High
Alopecia 2 63.04 Quite High
Muscle Hypotonia 16 60.44 Quite High
Pain 16 59.36 Quite High
Muscle Disease 2 58.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although mRNA expression of the IGF-1 receptor beta-chain (IGF-1R beta) did not change, protein level of the 200 kDa IGF-1Rbeta precursor was significantly increased by simvastatin in a dose-dependent manner.
Positive_regulation (change) of Transcription (expression) of IGF-1
1) Confidence 0.49 Published 2007 Journal J Toxicol Sci Section Abstract Doc Link 17327694 Disease Relevance 0.31 Pain Relevance 0.06
Although mRNA expression of the IGF-1 receptor beta-chain (IGF-1R beta) did not change, protein level of the 200 kDa IGF-1Rbeta precursor was significantly increased by simvastatin in a dose-dependent manner.
Positive_regulation (change) of Transcription (expression) of IGF-1
2) Confidence 0.48 Published 2007 Journal J Toxicol Sci Section Abstract Doc Link 17327694 Disease Relevance 0.31 Pain Relevance 0.06
To obtain a reliable assessment, we evaluated GH activity by measuring the mRNA and protein levels of IGF-I (insulin-like growth factor 1) and documented reduced Igf1 mRNA levels in liver, as well as reduced IGF1 protein levels in the serum, at 4 and 8 weeks of age.
Positive_regulation (measuring) of Transcription (levels) of IGF-I in liver
3) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.24 Pain Relevance 0
Administration of capsaicin increased tissue levels of IGF-I and IGF-I mRNA in various organs in wild-type (WT) mice, but not in CGRP-knock-out (CGRP-/-) mice.
Positive_regulation (increased) of Transcription (levels) of IGF-I associated with targeted disruption, qutenza and calcitonin gene-related peptide
4) Confidence 0.46 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.51 Pain Relevance 0.69
Administration of CGRP increased tissue levels of IGF-I and IGF-I mRNA in both WT and CGRP-/- mice.
Positive_regulation (increased) of Transcription (levels) of IGF-I associated with calcitonin gene-related peptide
5) Confidence 0.46 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.58 Pain Relevance 0.78
Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I and IGF-I mRNA in various organs via increased calcitonin gene-related peptide (CGRP) release in mice.
Positive_regulation (increases) of Transcription (levels) of IGF-I in sensory neurons associated with qutenza and calcitonin gene-related peptide
6) Confidence 0.46 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.37 Pain Relevance 0.36
For all other dietary treatments, such as low fat diets and CR mimetics, IGF-I transcript levels were not significantly affected, and in fact, were slightly upregulated in most cases (Fig. 1, Table 2).
Positive_regulation (upregulated) of Transcription (levels) of IGF-I in fat
7) Confidence 0.45 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0 Pain Relevance 0
Since Igf1 transcription increases in response to GH binding, these results indicate an abnormality in GH release and/or signaling in the deletion mice.
Positive_regulation (increases) of Transcription (transcription) of Igf1
8) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.12 Pain Relevance 0
Generally, growth hormone exposure induces hepatic IGF-I production by increasing transcription of IGF-I mRNA (41).
Positive_regulation (increasing) of Transcription (transcription) of IGF-I
9) Confidence 0.29 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063566 Disease Relevance 0 Pain Relevance 0

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