INT142343

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
liver 1
anterior pituitary 1
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 7 46.84 Quite Low
Neurobehavioral 6 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Pain threshold 2 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 88 97.16 Very High Very High Very High
Growth Problems 4 64.84 Quite High
Congenital Anomalies 3 60.92 Quite High
Disorders Of Creatine Metabolism 3 58.80 Quite High
Hyperphagia 24 50.00 Quite Low
Pain 8 46.84 Quite Low
Muscle Disease 1 45.56 Quite Low
Body Weight 15 18.00 Low Low
Muscle Hypotonia 8 10.32 Low Low
Obesity 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that simvastatin decreases IGF-1 signaling via a regulation of the post-translational modification of IGF-1Rbeta in an HMG-CoA reductase inhibition-independent manner.
Negative_regulation (decreases) of Regulation (regulation) of IGF
1) Confidence 0.41 Published 2007 Journal J Toxicol Sci Section Abstract Doc Link 17327694 Disease Relevance 0.06 Pain Relevance 0
Since we observed a reduction in liver Igf1 mRNA expression and in circulating levels of IGF1 protein, indicative of GH deficiency, and since most individuals with PWS are GH deficient, we studied the structure and development of the pituitary gland to determine whether the GH deficiency is caused by a structural pituitary defect or a reduction in the number of GH producing cells in the anterior pituitary.
Negative_regulation (reduction) of in liver Regulation (levels) of IGF1 in anterior pituitary associated with syndrome
2) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.29 Pain Relevance 0

General Comments

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