INT142344

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 7.55
Pain Relevance 6.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
liver 6
sensory neurons 2
fat 1
brains 1
pituitary gland 1
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 80 99.96 Very High Very High Very High
qutenza 48 99.72 Very High Very High Very High
Somatostatin 78 99.12 Very High Very High Very High
Hippocampus 18 95.20 Very High Very High Very High
spinal dorsal horn 2 88.80 High High
parabrachial 2 86.88 High High
antagonist 13 86.24 High High
ischemia 4 85.60 High High
agonist 16 78.68 Quite High
Dopamine 16 78.32 Quite High
Disease Link Frequency Relevance Heat
Aging 134 99.40 Very High Very High Very High
Disease 119 99.00 Very High Very High Very High
Targeted Disruption 53 97.56 Very High Very High Very High
Lifespan 99 97.34 Very High Very High Very High
Cancer 52 97.20 Very High Very High Very High
Apoptosis 40 96.88 Very High Very High Very High
Adenoma 23 96.88 Very High Very High Very High
Syndrome 444 95.80 Very High Very High Very High
Cognitive Disorder 46 92.92 High High
Neurodegenerative Disease 15 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although mRNA expression of the IGF-1 receptor beta-chain (IGF-1R beta) did not change, protein level of the 200 kDa IGF-1Rbeta precursor was significantly increased by simvastatin in a dose-dependent manner.
Transcription (expression) of IGF-1
1) Confidence 0.69 Published 2007 Journal J Toxicol Sci Section Abstract Doc Link 17327694 Disease Relevance 0.31 Pain Relevance 0.06
To obtain a reliable assessment, we evaluated GH activity by measuring the mRNA and protein levels of IGF-I (insulin-like growth factor 1) and documented reduced Igf1 mRNA levels in liver, as well as reduced IGF1 protein levels in the serum, at 4 and 8 weeks of age.
Transcription (levels) of Igf1 in liver
2) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.13 Pain Relevance 0
Although the most important effect of somatostatin analogs is the inhibition of GH secretion by the adenoma leading to a subsequent decrease in circulating liver-derived IGF-I, part of the peripheral effects of these analogs is caused by the direct inhibition of IGF-I gene transcription after binding to the somatostatin receptor (Serri et al 1992; Murray et al 2004).
Transcription (transcription) of IGF-I gene in liver associated with adenoma and somatostatin
3) Confidence 0.68 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.36 Pain Relevance 0.29
Although mRNA expression of the IGF-1 receptor beta-chain (IGF-1R beta) did not change, protein level of the 200 kDa IGF-1Rbeta precursor was significantly increased by simvastatin in a dose-dependent manner.
Transcription (expression) of IGF-1
4) Confidence 0.67 Published 2007 Journal J Toxicol Sci Section Abstract Doc Link 17327694 Disease Relevance 0.31 Pain Relevance 0.06
In fact, reduced IGF-I levels in circulation may be the main factor behind extended lifespan in dwarf mice, such that with respect to liver, the only expression change consequential for longevity determination is that of the IGF-I transcript.
Transcription (transcript) of IGF-I in liver associated with aging and lifespan
5) Confidence 0.66 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.97 Pain Relevance 0
By performing quantitative RT-PCR with liver RNA samples from 4-wk and 8-wk old mice, we found that Igf1 mRNA expression was significantly lower in the mutants at both time points, 76±8% of the WT level at 4 wk and 80±8% at 8 wk (both P<0.04) (Fig. 2C left).
Transcription (expression) of Igf1 in liver
6) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.30 Pain Relevance 0
To obtain a reliable assessment, we evaluated GH activity by measuring the mRNA and protein levels of IGF-I (insulin-like growth factor 1) and documented reduced Igf1 mRNA levels in liver, as well as reduced IGF1 protein levels in the serum, at 4 and 8 weeks of age.
Transcription (levels) of IGF-I in liver
7) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.24 Pain Relevance 0
Administration of CGRP increased tissue levels of IGF-I and IGF-I mRNA in both WT and CGRP-/- mice.
Transcription (levels) of IGF-I associated with calcitonin gene-related peptide
8) Confidence 0.53 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.57 Pain Relevance 0.77
Administration of capsaicin increased tissue levels of IGF-I and IGF-I mRNA in various organs in wild-type (WT) mice, but not in CGRP-knock-out (CGRP-/-) mice.
Transcription (levels) of IGF-I associated with targeted disruption, qutenza and calcitonin gene-related peptide
9) Confidence 0.53 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.51 Pain Relevance 0.70
Administration of capsaicin increased tissue levels of IGF-I and IGF-I mRNA in various organs in wild-type (WT) mice, but not in CGRP-knock-out (CGRP-/-) mice.
Transcription (levels) of IGF-I associated with targeted disruption, qutenza and calcitonin gene-related peptide
10) Confidence 0.53 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17360009 Disease Relevance 0.51 Pain Relevance 0.69
Significant increases of the hippocampal tissue levels of CGRP, IGF-I, and IGF-I messenger RNA (mRNA) were observed after capsaicin administration in WT mice (P < 0.01) but not in CGRP-/- mice.
Transcription (observed) of IGF-I associated with qutenza and calcitonin gene-related peptide
11) Confidence 0.53 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.51 Pain Relevance 1.09
Significant increases of the hippocampal tissue levels of CGRP, IGF-I, and IGF-I messenger RNA (mRNA) were observed after capsaicin administration in WT mice (P < 0.01) but not in CGRP-/- mice.
Transcription (observed) of IGF-I associated with qutenza and calcitonin gene-related peptide
12) Confidence 0.53 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.51 Pain Relevance 1.09
Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I and IGF-I mRNA in various organs via increased calcitonin gene-related peptide (CGRP) release in mice.
Transcription (levels) of IGF-I in sensory neurons associated with qutenza and calcitonin gene-related peptide
13) Confidence 0.52 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.38 Pain Relevance 0.37
Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I and IGF-I mRNA in various organs via increased calcitonin gene-related peptide (CGRP) release in mice.
Transcription (levels) of IGF-I in sensory neurons associated with qutenza and calcitonin gene-related peptide
14) Confidence 0.52 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.37 Pain Relevance 0.36
For all other dietary treatments, such as low fat diets and CR mimetics, IGF-I transcript levels were not significantly affected, and in fact, were slightly upregulated in most cases (Fig. 1, Table 2).
Transcription (levels) of IGF-I in fat
15) Confidence 0.51 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0 Pain Relevance 0
Since Igf1 transcription increases in response to GH binding, these results indicate an abnormality in GH release and/or signaling in the deletion mice.
Transcription (transcription) of Igf1
16) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.12 Pain Relevance 0
Since we observed a reduction in liver Igf1 mRNA expression and in circulating levels of IGF1 protein, indicative of GH deficiency, and since most individuals with PWS are GH deficient, we studied the structure and development of the pituitary gland to determine whether the GH deficiency is caused by a structural pituitary defect or a reduction in the number of GH producing cells in the anterior pituitary.
Transcription (expression) of Igf1 in pituitary gland associated with syndrome
17) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.28 Pain Relevance 0
Although the most important effect of somatostatin analogs is the inhibition of tumor-derived GH and the subsequent fall in circulating liver-derived IGF-I, part of the peripheral effects are caused by a direct inhibition of IGF-I gene transcription via activation after binding to the somatostatin receptor (Serri et al 1992; Le Roith et al 2001; Murray et al 2004).
Transcription (transcription) of IGF-I gene in liver associated with cancer and somatostatin
18) Confidence 0.43 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.18 Pain Relevance 0.48
Generally, growth hormone exposure induces hepatic IGF-I production by increasing transcription of IGF-I mRNA (41).
Transcription (transcription) of IGF-I
19) Confidence 0.41 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063566 Disease Relevance 0 Pain Relevance 0
Transcription of the genes for insulin and IGF1 receptors is reduced in AD brains compared with controls [80, 81].
Transcription (Transcription) of IGF1 in brains associated with disease
20) Confidence 0.35 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.41 Pain Relevance 0.04

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