INT142345

Context Info Confidence 0.42 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.33 Pain Relevance 0.06

transport (Akt1) aging (Akt1) enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)

Igf1 (Mus musculus) Akt1 (Mus musculus)

Pain Link Frequency Relevance Heat Pain 1 62.80

Disease Link Frequency Relevance Heat Disorders Of Creatine Metabolism 3 74.76 Pain 1 62.80 Muscle Disease 1 61.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

After induction of differentiation in the presence of 1 microM simvastatin for 2 days, IGF-1-induced activation of ERK1/2 and Akt was significantly decreased.

Negative_regulation (decreased) of IGF-1-induced Positive_regulation (activation) of Akt

1) Confidence 0.42 Published 2007 Journal J Toxicol Sci Section Abstract Doc Link 17327694 Disease Relevance 0.33 Pain Relevance 0.06

General Comments

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