INT142348

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
Fibroblast 1
Igf1 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 62.80 Quite High
Eae 6 30.48 Quite Low
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 127 92.16 High High
Apoptosis 133 83.04 Quite High
Stress 32 77.64 Quite High
Aging 5 75.72 Quite High
Disorders Of Creatine Metabolism 3 74.76 Quite High
Death 56 70.80 Quite High
Toxicity 15 68.32 Quite High
Pain 1 62.80 Quite High
Muscle Disease 1 61.52 Quite High
Diabetes Mellitus 1 50.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After induction of differentiation in the presence of 1 microM simvastatin for 2 days, IGF-1-induced activation of ERK1/2 and Akt was significantly decreased.
IGF-1-induced Positive_regulation (activation) of Akt
1) Confidence 0.50 Published 2007 Journal J Toxicol Sci Section Abstract Doc Link 17327694 Disease Relevance 0.33 Pain Relevance 0.06
is phosphorylated (and inactivated) through a PI3K/Akt signaling pathway induced by IGF-1, NGF and any growth factor whose activity is mediated by receptors with intrinsic tyrosine kinase activity [201], including also Fibroblast Growth Factor-2 (FGF-2).
IGF-1 Positive_regulation (induced) of Akt in Fibroblast
2) Confidence 0.00 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.83 Pain Relevance 0

General Comments

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