INT14235

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Context Info
Confidence 0.04
First Reported 1990
Last Reported 1994
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.16
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
L1210 2
blood 1
Babr (Mus musculus)
Pain Link Frequency Relevance Heat
vincristine 14 100.00 Very High Very High Very High
Sciatic nerve 2 98.08 Very High Very High Very High
Action potential 2 97.66 Very High Very High Very High
lidocaine 2 95.36 Very High Very High Very High
Dopamine 12 89.36 High High
Calcium channel 2 88.40 High High
dopamine receptor 2 25.00 Low Low
anesthesia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 4 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, significant positive correlations were observed between both the inhibitory action of local anaesthetics on propagation of action potential in rat sciatic nerve and the ability of drugs to interact with calmodulin and the ability of the respective drug to reverse the resistance of L1210 cells to vincristine.
Negative_regulation (reverse) of resistance in L1210 associated with vincristine, action potential and sciatic nerve
1) Confidence 0.04 Published 1994 Journal Drugs Exp Clin Res Section Abstract Doc Link 7924890 Disease Relevance 0 Pain Relevance 0.41
Quaternary cabanilate derivatives (Ca7Q and Ca3Q) with permanent positive charge were found to be unable to reverse the vincristine resistance of L1210/VCR cells.
Neg (unable) Negative_regulation (reverse) of resistance in L1210 associated with vincristine
2) Confidence 0.04 Published 1994 Journal Drugs Exp Clin Res Section Abstract Doc Link 7924890 Disease Relevance 0 Pain Relevance 0.46
Furthermore, at a lower dose of TA-870 (2 mg/kg), renal vascular resistance (RVR) decreased and renal blood flow (RBF) increased.
Negative_regulation (decreased) of resistance in blood
3) Confidence 0.01 Published 1990 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1689425 Disease Relevance 0.08 Pain Relevance 0.19
Similarly, total peripheral resistance (TPR) decreased and cardiac output (CO) increased at less than 4 mg/kg.
Negative_regulation (decreased) of resistance
4) Confidence 0.01 Published 1990 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1689425 Disease Relevance 0.08 Pain Relevance 0.20

General Comments

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