INT142355

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.08
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Tpmt)
Anatomy Link Frequency
bone marrow 1
Tpmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 1 100.00 Very High Very High Very High
antidepressant 1 99.56 Very High Very High Very High
Inflammation 4 88.48 High High
corticosteroid 4 25.00 Low Low
Codeine 2 25.00 Low Low
cINOD 2 25.00 Low Low
Crohn's disease 2 25.00 Low Low
Infliximab 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Depression 1 100.00 Very High Very High Very High
Muscle Disease 1 94.44 High High
Inflammatory Bowel Disease 18 89.24 High High
Adverse Drug Reaction 3 82.52 Quite High
Hepatotoxicity 2 43.60 Quite Low
Pancreatitis 2 42.32 Quite Low
Disease 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The catabolic enzyme thiopurine S-methyltransferase (TPMT) is polymorphically expressed, and currently 23 genetic variants have been described.
Gene_expression (expressed) of thiopurine S-methyltransferase
1) Confidence 0.70 Published 2007 Journal Clin Pharmacokinet Section Abstract Doc Link 17328579 Disease Relevance 0.40 Pain Relevance 0.08
The catabolic enzyme thiopurine S-methyltransferase (TPMT) is polymorphically expressed, and currently 23 genetic variants have been described.
Gene_expression (expressed) of TPMT
2) Confidence 0.70 Published 2007 Journal Clin Pharmacokinet Section Abstract Doc Link 17328579 Disease Relevance 0.40 Pain Relevance 0.08
Examples include genotyping of CYP2D6 in the context of antidepressant therapy, analysis of TPMT variants for the prediction of mercaptopurine-induced bone marrow depression, VKORC1 and CYP2C9 analyses for a better control of anticoagulant administration and the SLCO1B1 variant in the context of statin-induced myopathies.
Spec (analyses) Gene_expression (depression) of TPMT in bone marrow associated with antidepressant, depression and muscle disease
3) Confidence 0.09 Published 2010 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 20101557 Disease Relevance 0.28 Pain Relevance 0.10

General Comments

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