INT14238

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Context Info
Confidence 0.60
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 17.75
Pain Relevance 6.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 6
B cells 1
MdLN 1
neutrophil 1
Cd69 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 105 100.00 Very High Very High Very High
ectopic activity 86 100.00 Very High Very High Very High
ischemia 8 99.80 Very High Very High Very High
depression 6 99.30 Very High Very High Very High
Arthritis 88 98.76 Very High Very High Very High
abatacept 6 92.84 High High
rheumatoid arthritis 35 91.88 High High
Inflammation 180 90.40 High High
Angina 13 85.04 High High
agonist 20 81.12 Quite High
Disease Link Frequency Relevance Heat
Premature Ventricular Beats 78 100.00 Very High Very High Very High
Arrhythmia Under Development 20 100.00 Very High Very High Very High
Cv Unclassified Under Development 8 99.80 Very High Very High Very High
Depression 6 99.30 Very High Very High Very High
Infection 474 99.28 Very High Very High Very High
Disease 107 98.84 Very High Very High Very High
Death 30 98.84 Very High Very High Very High
Arthritis 92 98.76 Very High Very High Very High
Splenomegaly 16 98.28 Very High Very High Very High
Lymphatic System Cancer 56 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ag-specific T cell proliferation was reduced, and the acquisition of an activated phenotype, characterized by upregulation of CD69, OX40, ICOS, and programmed death-1 and downregulation of CD62L, was suppressed.
Positive_regulation (upregulation) of CD69 in T cell associated with death
1) Confidence 0.60 Published 2010 Journal J. Immunol. Section Abstract Doc Link 20601593 Disease Relevance 0.59 Pain Relevance 0.69
HV68 infection results in polyclonal activation of B cells, characterized by an upregulation of the CD69 activation marker and an increase in nonspecific antibody production, a process that is dependent on CD4+ T cells [43,70,71].
Positive_regulation (upregulation) of CD69 in T cells associated with infection
2) Confidence 0.50 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.36 Pain Relevance 0.05
It is very unlikely that each of these mutated ORFs has a direct role in CD69 upregulation, as acute titers were normal for each mutant.
Positive_regulation (upregulation) of CD69
3) Confidence 0.50 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.33 Pain Relevance 0
HV68, as with these other mutants after intranasal infection, substantiates the conclusion that CD69 activation correlates with differences in the levels of splenic latency and extends that correlation to latency in B cells at the primary site of infection.
Positive_regulation (activation) of CD69 in B cells associated with infection
4) Confidence 0.50 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.35 Pain Relevance 0
A reduction in CD69 activation has been correlated to both a decrease in splenomegaly and splenic latency in mice infected with ?
Positive_regulation (activation) of CD69 associated with splenomegaly
5) Confidence 0.50 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.37 Pain Relevance 0
However, a rapid upregulation of the activation marker CD69 was observed on the NK cells in the MdLN already after one day, and in the lungs starting from day 2.
Positive_regulation (upregulation) of CD69 in MdLN
6) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.52 Pain Relevance 0
Since CD69 is upregulated in proliferating T–cells in a TCR–dependent manner [20], these results suggest that the proliferation of those leukemia/lymphoma cells occurs independently of TCR engagement.
Positive_regulation (upregulated) of CD69 in T-cells associated with leukemia and lymphatic system cancer
7) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.23 Pain Relevance 0
In 83% of these episodes the increased VEA appeared during the last (possibly reperfusion) phase.
Positive_regulation (increased) of VEA associated with ectopic activity
8) Confidence 0.36 Published 1990 Journal Am. J. Cardiol. Section Abstract Doc Link 1689533 Disease Relevance 1.25 Pain Relevance 0.59
No correlation was found between the severity of the ischemic episodes (degree of ST depression and duration of ischemia) and the increased VEA.
Positive_regulation (increased) of VEA associated with depression, ischemia and ectopic activity
9) Confidence 0.36 Published 1990 Journal Am. J. Cardiol. Section Abstract Doc Link 1689533 Disease Relevance 1.32 Pain Relevance 0.60
Forty-three patients had either no or only very low baseline VEA (less than 14 ventricular premature complexes [VPCs]/24 hours); none of these patients had increased VEA during any ischemic episode.
Positive_regulation (increased) of VEA associated with ectopic activity and premature ventricular beats
10) Confidence 0.36 Published 1990 Journal Am. J. Cardiol. Section Abstract Doc Link 1689533 Disease Relevance 1.15 Pain Relevance 0.46
These 11 patients had a total of 174 ischemic episodes and the increased VEA appeared in 47 (27%) of the episodes.
Positive_regulation (increased) of VEA associated with ectopic activity
11) Confidence 0.36 Published 1990 Journal Am. J. Cardiol. Section Abstract Doc Link 1689533 Disease Relevance 1.45 Pain Relevance 0.60
Among the 11 patients with increased VEA, only 4 developed VPCs during treadmill testing.
Positive_regulation (increased) of VEA associated with ectopic activity
12) Confidence 0.36 Published 1990 Journal Am. J. Cardiol. Section Abstract Doc Link 1689533 Disease Relevance 1.52 Pain Relevance 0.69
However, among 32 patients who had greater than or equal to 14 VPCs/24 hours (average 243 VPCs/24 hours), increased VEA during ischemic episodes was observed in 11 (31%).
Positive_regulation (increased) of VEA associated with ectopic activity
13) Confidence 0.36 Published 1990 Journal Am. J. Cardiol. Section Abstract Doc Link 1689533 Disease Relevance 1.30 Pain Relevance 0.53
In lung digests, sub acute and chronic CS-exposure induced increases in DCs and activated (CD69+) CD4+ and CD8+ T-lymphocytes.
Positive_regulation (activated) of CD69 in T-lymphocytes
14) Confidence 0.36 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.22 Pain Relevance 0.06
A positive regulatory role for CD69 in neutrophil function during arthritis induction in CAIA was reported [71], but a recent study ruled out such a significant stimulatory role for it [72].
Positive_regulation (role) of CD69 in neutrophil associated with arthritis
15) Confidence 0.33 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.37 Pain Relevance 0.77
Sexual activity did not significantly elicit more VEA than other activities of the awake state.
Neg (not) Positive_regulation (elicit) of VEA associated with ectopic activity
16) Confidence 0.32 Published 1981 Journal G Ital Cardiol Section Abstract Doc Link 7239094 Disease Relevance 1.76 Pain Relevance 0.60
Interestingly, following an extensive flow cytometric analysis of lung digests, the only significant differences observed were on the percentage of activated (CD69+) CD4 and CD8 T cells.
Positive_regulation (activated) of CD69 in T cells
17) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2953496 Disease Relevance 0.71 Pain Relevance 0.13
A detailed examination of the gene profiles was employed using the signal to noise ratio, ANOVA, Student's t-test, and fold changes, and resulted in fifteen genes that are potential biomarkers of disease progression in need of further testing: SERPINC1 (462), DHFRL1 (200895), IRX2 (153572), SGCE (8910), ADAM23 (8745), TBX3 (6926), SLC5A4 (6527), CCAR1 (55749), MS4A2 (2206), IMPACT (55364), NDUFA5 (4698), CEACAM6 (4680), C10orf88 (80007), ITGA4 (3676), and CD69 (969) (first seven genes are upregulated and the subsequent eight genes are downregulated).
Positive_regulation (upregulated) of CD69 associated with disease progression
18) Confidence 0.24 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.57 Pain Relevance 0
In addition to increases in cytokine levels cellular markers for T-cell activation, CD69, CD38, and CCR7 have been shown to be increased in dengue infection[33] and IFN?
Positive_regulation (increases) of CD69 in T-cell associated with dengue, infection and cytokine
19) Confidence 0.22 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 1.38 Pain Relevance 0.29

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