INT142404
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
These activities of eltrombopag have been shown to be dependent on the expression of TPO receptor. | |||||||||||||||
| |||||||||||||||
|
Physiologic control of TPO production | |||||||||||||||
| |||||||||||||||
|
Malignant hemopoietic cells are known to express TPO receptors and there is a theoretical risk that TPO growth factors may stimulate growth of malignant cells. | |||||||||||||||
| |||||||||||||||
|
Laboratory findings were as follow: erythrocyte sedimentation rate 85 mm/h, C-reactive protein 143 mg/L, white cell count of 11 x 10(9)/L (3.0-9.6), TSH 0.10 mU/L (0.27-4.20), fT4 24.2 pmol/L (12-22), fT3 5.5 pmol/L (2.8-7.1) antinuclear antibodies 1:80, antithyreoglobulin antibodies 212 IE/ml (< 100), thyreoglobulin 442 microg/L, anti-TPO normal and TSH receptor antibodies were negative. | |||||||||||||||
| |||||||||||||||
|
Significantly elevated endogenous TPO levels have been observed in disorders in which there is diminished platelet production and therefore reduced TPO clearance, although thrombopoietin levels are typically normal in patients with ITP. | |||||||||||||||
| |||||||||||||||
|
Significantly elevated endogenous TPO levels have been observed in disorders in which there is diminished platelet production and therefore reduced TPO clearance, although thrombopoietin levels are typically normal in patients with ITP. | |||||||||||||||
| |||||||||||||||
|
The TPO receptor is found on megakaryocyte precursor cells, megakaryocytes, and platelets, as well as on stem cells and early bone marrow progenitor cells of all lineages.
| |||||||||||||||
| |||||||||||||||
|
Significantly elevated endogenous TPO levels have been observed in disorders in which there is diminished platelet production and therefore reduced TPO clearance, although thrombopoietin levels are typically normal in patients with ITP. | |||||||||||||||
| |||||||||||||||
|
However, clinical development of both recombinant TPOs was ultimately discontinued and many of the clinical studies undertaken between 1994 and 1999 remain unpublished.15
Alternative TPO agonists | |||||||||||||||
| |||||||||||||||
|
However, clinical development of both recombinant TPOs was ultimately discontinued and many of the clinical studies undertaken between 1994 and 1999 remain unpublished.15
Alternative TPO agonists | |||||||||||||||
| |||||||||||||||
|
Detection of anti-smooth muscle (SMA), anti-mitochondrial (AMA), anti-liver kidney microsomes (LKM), anti-thyroid peroxidase (TPO), anti-thyroglobulin (TG) and anti-adrenal (ADA) autoantibodies | |||||||||||||||
| |||||||||||||||
|
The TPO receptor is found on megakaryocyte precursor cells, megakaryocytes, and platelets, as well as on stem cells and early bone marrow progenitor cells of all lineages.
| |||||||||||||||
| |||||||||||||||
|
The TPO receptor is found on megakaryocyte precursor cells, megakaryocytes, and platelets, as well as on stem cells and early bone marrow progenitor cells of all lineages.
| |||||||||||||||
| |||||||||||||||
|
The most frequently detected autoantibodies were reactive with TPO, TG and nucleus (in all instances in three patients). | |||||||||||||||
| |||||||||||||||
|
In other studies, McGuckin et al demonstrated that culture of cord blood cells that have been depleted of lineage committed cells in a TPO, c-kit, and flt-3 ligand culture express markers of embryonic stem cells including TRA-160, TRA-181, SSEA-4, SSEA-3 and Oct-4. | |||||||||||||||
| |||||||||||||||
|
PU.1 promotes the cell-type-specific expression of the myeloid lineage genes CD11b, CD11c, CD18, the granulocyte colony-stimulating factor (CSF) receptor, the granulocytemacrophage CSF receptor, and the macrophage CSF receptor (c-fms) via binding to these genes' promoter regions [18]. | |||||||||||||||
| |||||||||||||||
|
We applied TCD and NIRS during baseline conditions and during CO2 reactivity. | |||||||||||||||
| |||||||||||||||
|
Lee YS, Wang TH, Chen ES, Wei ML, Chen LK carried out the microarray experiments. | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.