INT142416

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.92
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptch1) extracellular region (Ptch1) plasma membrane (Ptch1)
Anatomy Link Frequency
brain 1
Ptch1 (Mus musculus)
Pain Link Frequency Relevance Heat
Gabapentin 9 98.18 Very High Very High Very High
Potency 1 98.00 Very High Very High Very High
cytokine 20 76.00 Quite High
antagonist 1 69.84 Quite High
anticonvulsant 2 52.72 Quite High
tolerance 12 47.68 Quite Low
antiepileptic Drug 1 47.36 Quite Low
Enkephalin 1 25.00 Low Low
Pain 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 184 100.00 Very High Very High Very High
Hyperglycemia 14 99.48 Very High Very High Very High
Cancer 54 99.28 Very High Very High Very High
Skin Cancer 6 98.60 Very High Very High Very High
Malignant Neoplastic Disease 11 97.44 Very High Very High Very High
Diabetes Mellitus 22 91.44 High High
Obesity 20 91.00 High High
Ataxia 2 89.40 High High
Medulloblastoma 30 87.36 High High
Basal Cell Carcinoma 46 86.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If a mutation occurs in PTCH1 and the second loop is not formed, SHH cannot bind.
PTCH1 Neg (cannot) Binding (bind) of
1) Confidence 0.34 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 0.45 Pain Relevance 0
This compound binds Ptc and Smo in the Shh receptor complex and inhibits Shh signaling [14,19].


Ptc Binding (binds) of
2) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.13 Pain Relevance 0
Upon Shh binding to the receptor composed of patched 1 (Ptc) and Smoothend (Smo), the Shh signal transmitter, Gli members, are activated and translocated to the cell nuclei for gene expression regulation.
patched 1 Binding (binding) of
3) Confidence 0.30 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.65 Pain Relevance 0.04
Upon Shh binding to the receptor composed of patched 1 (Ptc) and Smoothend (Smo), the Shh signal transmitter, Gli members, are activated and translocated to the cell nuclei for gene expression regulation.
Ptc Binding (binding) of
4) Confidence 0.30 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.65 Pain Relevance 0.04
However, this was not a complete loss of function, suggesting that these mutations may affect the interaction with the receptor PTCH1 or its partners, with an impact on the induction potency.
PTCH1 Binding (interaction) of associated with potency
5) Confidence 0.28 Published 2010 Journal Cell. Mol. Biol. Lett. Section Abstract Doc Link 20024692 Disease Relevance 0.08 Pain Relevance 0.08
Cells were treated for 10 min with HS and MES, and lysates were isolated at the indicated time points.
MES Binding (min) of associated with shock
6) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.01 Pain Relevance 0
Treatment with HS+MES ameliorated hyperglycemia in db/db mice
MES Binding (Treatment) of associated with hyperglycemia and shock
7) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.64 Pain Relevance 0
The evaluation of pharmacokinetic characteristics of interaction for the combination of TPM with GBP revealed that neither TPM nor GBP affected their total brain concentrations in experimental animals, and thus, the observed interaction in the MES test was pharmacodynamic in nature.
MES Binding (interaction) of in brain associated with gabapentin
8) Confidence 0.12 Published 2007 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 17333129 Disease Relevance 0.31 Pain Relevance 0.58

General Comments

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