INT142417

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.63
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
hypothalamus 4
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 1 83.80 Quite High
anesthesia 1 81.16 Quite High
depression 6 63.96 Quite High
cytokine 1 63.12 Quite High
Central nervous system 10 32.16 Quite Low
ketamine 4 5.00 Very Low Very Low Very Low
noradrenaline 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
acular 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 12 100.00 Very High Very High Very High
Acute Necrotizing Pancreatitis 8 100.00 Very High Very High Very High
Body Weight 22 95.76 Very High Very High Very High
Necrosis 1 87.44 High High
Cancer 1 87.08 High High
Thyroid Disease 54 70.36 Quite High
Depression 16 63.96 Quite High
Anxiety Disorder 18 63.36 Quite High
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This can be explained because hypothyroid rats had an enhanced transcription of mRNA for leptin21 and its concentration in serum.22 Leptin acts on the hypothalamus producing an anorexigenic effect so that hypothyroid pups have a lower appetite than euthyroid animals.
Positive_regulation (enhanced) of Transcription (transcription) of leptin21 in hypothalamus
1) Confidence 0.52 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874337 Disease Relevance 0.49 Pain Relevance 0.03
Serum leptin levels in the AEP and ANP groups increased after 12 hr and stayed at high levels until 48 hr compared with the control group.
Positive_regulation (increased) of Transcription (levels) of Serum leptin associated with pancreatitis and acute necrotizing pancreatitis
2) Confidence 0.40 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17333355 Disease Relevance 1.64 Pain Relevance 0.15
This can be explained because hypothyroid rats had an enhanced transcription of mRNA for leptin21 and its concentration in serum.22 Leptin acts on the hypothalamus producing an anorexigenic effect so that hypothyroid pups have a lower appetite than euthyroid animals.
Positive_regulation (enhanced) of Transcription (transcription) of leptin21 in hypothalamus
3) Confidence 0.38 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874337 Disease Relevance 0.49 Pain Relevance 0.03

General Comments

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