INT142435

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 86
Total Number 91
Disease Relevance 47.53
Pain Relevance 4.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (NES) intracellular (NES) molecular_function (NES)
cytoplasm (NES)
Anatomy Link Frequency
stem cell 11
neural 7
brain 4
neuronal 4
GBM 2
NES (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 80 100.00 Very High Very High Very High
antagonist 64 99.78 Very High Very High Very High
Dopamine 212 99.54 Very High Very High Very High
cytokine 34 99.46 Very High Very High Very High
withdrawal 23 98.96 Very High Very High Very High
Inflammation 47 98.52 Very High Very High Very High
ischemia 88 97.96 Very High Very High Very High
Central nervous system 268 90.28 High High
Neurotransmitter 167 88.76 High High
imagery 60 87.00 High High
Disease Link Frequency Relevance Heat
Glioma 2052 99.88 Very High Very High Very High
Glioblastoma 460 99.86 Very High Very High Very High
Brain Tumor 250 99.84 Very High Very High Very High
Familial Dysautonomia 242 99.80 Very High Very High Very High
Malignant Neoplastic Disease 179 99.64 Very High Very High Very High
Cancer 1643 99.52 Very High Very High Very High
Anaplastic Astrocytoma 120 99.44 Very High Very High Very High
Injury 90 98.68 Very High Very High Very High
INFLAMMATION 47 98.52 Very High Very High Very High
Aggression 40 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We assessed directional coronary atherectomy specimens from primary and restenotic lesions for expression of nestin.
Gene_expression (expression) of nestin
1) Confidence 0.78 Published 2007 Journal Int. J. Cardiol. Section Abstract Doc Link 17335923 Disease Relevance 0 Pain Relevance 0.07
Immunohistochemistry showed predominant expression of nestin in stellate smooth muscle cells (SMCs).
Gene_expression (expression) of nestin in SMCs
2) Confidence 0.78 Published 2007 Journal Int. J. Cardiol. Section Abstract Doc Link 17335923 Disease Relevance 0 Pain Relevance 0.07
The association of Nestin and CD133 expression with the 5-year survival rate of patients with gliomas was analyzed using Kaplan-Meier analysis.
Spec (analyzed) Gene_expression (expression) of Nestin associated with glioma
3) Confidence 0.75 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.66 Pain Relevance 0
In our small series of cases, Nestin and CD133 expression was associated with a poor prognosis and correlated better with clinical course than the histological grading.
Gene_expression (expression) of Nestin
4) Confidence 0.75 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.69 Pain Relevance 0.09
Furthermore, according to the conjoined expression of Nestin/CD133, the patients were categorized into four groups: Nestin-/CD133-, Nestin-/CD133+, Nestin+/CD133-, and Nestin+/CD133+.
Gene_expression (expression) of Nestin
5) Confidence 0.75 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.45 Pain Relevance 0
The expression of Nestin in different astrocytoma cell lines has been related to a migratory cell phenotype with increased motility and invasiveness of different astrocytoma cell lines [23].
Gene_expression (expression) of Nestin associated with anaplastic astrocytoma
6) Confidence 0.75 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 1.50 Pain Relevance 0.12
The results by pairwise comparisons showed that there is a significant difference in survival rates between patients with Nestin and CD133 strong positive expression and any of the other two groups (p < 0.01).
Gene_expression (expression) of Nestin
7) Confidence 0.75 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.51 Pain Relevance 0
While the prognostic significance of the histological diagnosis strongly depends on the experience of the respective neuropathologist, analysis of both available data sets revealed that Nestin and CD133 expression was superior in predicting the patient's survival.
Gene_expression (expression) of Nestin in superior
8) Confidence 0.75 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.47 Pain Relevance 0.04
The Chi-square value by Mantel-Cox indicated a significant difference among different groups with regard to the expression status of Nestin and CD133 (p < 0.01) (Table 3, Figure 2A and 2B).
Gene_expression (expression) of Nestin
9) Confidence 0.75 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.56 Pain Relevance 0
It has been reported that TSC expressing the markers Nestin and CD133 in a variety of brain tumors [13].
Gene_expression (expressing) of Nestin in brain associated with brain tumor
10) Confidence 0.75 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.60 Pain Relevance 0
Furthermore, the Spearman correlations (rs) were 0.89 (p = 0.02) indicating that the expression level of Nestin was positively correlated with that of CD133 significantly.


Gene_expression (expression) of Nestin
11) Confidence 0.75 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.73 Pain Relevance 0
Therefore, the purpose of this study is to determine the correlation of Nestin and CD133 expression with the grading of gliomas and their predictive efficiency in clinical outcome of patients.


Gene_expression (expression) of Nestin associated with glioma
12) Confidence 0.75 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.51 Pain Relevance 0
To evaluate whether a correlation between the expression of Nestin, CD133 and the pathological grades of gliomas could be observed a bi-variate correlation analysis (Pearson correlation coefficients) was done.
Gene_expression (expression) of Nestin associated with glioma
13) Confidence 0.75 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.78 Pain Relevance 0
The expression of GFAP and nestin characterized the central parts of the tumour.
Gene_expression (expression) of nestin associated with cancer
14) Confidence 0.75 Published 2008 Journal Folia Neuropathol Section Abstract Doc Link 18587711 Disease Relevance 0.88 Pain Relevance 0.13
Nestin has been detected in brain tumors such as pilocytic astrocytomas and malignant gliomas including GBM [22-25].
Gene_expression (detected) of Nestin in GBM associated with anaplastic astrocytoma, glioblastoma, glioma and brain tumor
15) Confidence 0.66 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 1.25 Pain Relevance 0.14
Nestin is an intermediate filament (IF) protein expressed in proliferating cells during the developmental stages in a variety of embryonic and fetal tissues [9].
Gene_expression (expressed) of Nestin in developmental stages
16) Confidence 0.66 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 1.03 Pain Relevance 0.06
Statistically significant correlations between the percentages of immunostained cells and pathological grades of gliomas were found for Nestin (cp = 0.592, p < 0.01) and CD133 (cp = 0.563, p = 0.01), which means that with higher malignant grades of gliomas, higher protein expression could be found.
Gene_expression (found) of Nestin associated with malignant neoplastic disease and glioma
17) Confidence 0.65 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.85 Pain Relevance 0
Nestin is a type of intermediate filament abundantly expressed in neuroepithelial stem cells or mesenchymal stem cells.
Gene_expression (expressed) of Nestin in stem cells
18) Confidence 0.60 Published 2007 Journal Int. J. Cardiol. Section Abstract Doc Link 17335923 Disease Relevance 0 Pain Relevance 0.05
The Spearman correlation was calculated between the expression levels of Nestin and CD133 in glioma tissues.
Gene_expression (levels) of Nestin associated with glioma
19) Confidence 0.58 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.69 Pain Relevance 0
The survival rate of the patients with Nestin+/CD133+ expression was the lowest (p < 0.01), and the multivariate analysis confirmed that conjoined expression of Nestin+/CD133+ and Nestin-/CD133- were independent prognostic indicators of gliomas (both p < 0.01, Cox proportional hazard regression model).


Gene_expression (expression) of Nestin associated with glioma
20) Confidence 0.58 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2633002 Disease Relevance 0.85 Pain Relevance 0

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