INT142437

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.12
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
nucleolus (Urb1) cytoplasm (Faah)
Anatomy Link Frequency
brain 1
Urb1 (Rattus norvegicus)
Faah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endocannabinoid 7 100.00 Very High Very High Very High
Hyperalgesia 5 99.60 Very High Very High Very High
Endogenous opioid 3 98.36 Very High Very High Very High
Pain 5 97.08 Very High Very High Very High
Analgesic 2 97.08 Very High Very High Very High
Cannabinoid 4 88.16 High High
Bile 1 86.56 High High
analgesia 1 86.48 High High
tail-flick 5 77.04 Quite High
Dopamine 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 6 99.60 Very High Very High Very High
Nociception 4 99.22 Very High Very High Very High
Diabetes Mellitus 9 98.96 Very High Very High Very High
Pain 3 97.08 Very High Very High Very High
Gallstones 5 95.72 Very High Very High Very High
Hyperglycemia 1 73.56 Quite High
Body Weight 1 58.36 Quite High
Sleep Disorders 1 25.00 Low Low
Diabetic Neuropathy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats.
URB597 Negative_regulation (inhibitor) of fatty acid amide hydrolase associated with endocannabinoid, hyperalgesia and diabetes mellitus
1) Confidence 0.41 Published 2009 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 19526037 Disease Relevance 1.35 Pain Relevance 0.74
Considering the interaction that has been shown between the endogenous opioid and endocannabinoid systems in nociception processing, we studied the effects of URB597, a selective inhibitor of FAAH (fatty acid amide hydrolase), on modulation of nociception in a model of elevated endogenous opioid tone, cholestasis.
URB597 Negative_regulation (inhibitor) of FAAH associated with nociception, endocannabinoid, endogenous opioid and gallstones
2) Confidence 0.18 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18593578 Disease Relevance 0.77 Pain Relevance 0.75
It has been demonstrated that the inhibition of the FAAH by URB597 increases levels of anandamide, oleoylethanolamide and palmitoylethanolamide in the brain of rats.
URB597 Negative_regulation (inhibition) of FAAH in brain
3) Confidence 0.12 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17336288 Disease Relevance 0 Pain Relevance 0.18

General Comments

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