INT142451

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.00
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGIS) small molecule metabolic process (PTGIS) endoplasmic reticulum (PTGIS)
lipid metabolic process (PTGIS)
Anatomy Link Frequency
smooth muscle cell 4
PTGIS (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 1 98.68 Very High Very High Very High
cytokine 1 89.56 High High
Inflammation 3 89.16 High High
cINOD 1 78.00 Quite High
COX2 2 25.00 Low Low
agonist 6 22.44 Low Low
local anesthetic 2 15.28 Low Low
Pain 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 102 99.78 Very High Very High Very High
Insulin Resistance 2 96.40 Very High Very High Very High
Necrosis 1 94.56 High High
Cancer 1 94.20 High High
Adhesions 2 93.76 High High
Disorder Of Lipid Metabolism 2 91.92 High High
INFLAMMATION 4 89.16 High High
Hyperlipidemia 4 88.16 High High
Hypertension 2 87.40 High High
Atherosclerosis 6 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, elevated levels of prostacyclin secretion stimulated by TNF-alpha were markedly down-regulated by indomethacin and a selective COX-2 inhibitor.
Negative_regulation (down-regulated) of Localization (secretion) of prostacyclin associated with cox-2 inhibitor
1) Confidence 0.50 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 17337058 Disease Relevance 0.28 Pain Relevance 0.22
However, in vitro studies have shown that the smoking particles have many effects on endothelial and smooth muscle cells; eg, reduce prostacyclin release and eNOS expression in endothelial cells (Sun et al 1998), induce smooth muscle cell proliferation (Xu et al 1994) and enhance expression of vascular cell adhesion molecular (Chen et al 2004).
Negative_regulation (reduce) of Localization (release) of prostacyclin in smooth muscle cell associated with nicotine addiction and adhesions
2) Confidence 0.04 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515430 Disease Relevance 0.75 Pain Relevance 0
The combination of LDL with lipid soluble smoking particles reduces the release of prostacyclin from arterial endothelial cells and enhances arterial smooth muscle cell proliferation (Xu et al 1994).
Negative_regulation (reduces) of Localization (release) of prostacyclin in smooth muscle cell associated with nicotine addiction
3) Confidence 0.03 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515430 Disease Relevance 0.97 Pain Relevance 0

General Comments

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