INT142452

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.72
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGIS) small molecule metabolic process (PTGIS) endoplasmic reticulum (PTGIS)
lipid metabolic process (PTGIS)
PTGIS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 99.34 Very High Very High Very High
Inflammation 3 99.14 Very High Very High Very High
bradykinin 11 98.88 Very High Very High Very High
antagonist 2 89.16 High High
COX-2 inhibitor 2 75.12 Quite High
cINOD 2 55.76 Quite High
COX2 4 25.00 Low Low
aspirin 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.14 Very High Very High Very High
Cancer 2 95.76 Very High Very High Very High
Necrosis 2 95.28 Very High Very High Very High
Pre-eclampsia 33 61.44 Quite High
Placenta Accreta 1 48.32 Quite Low
Spontaneous Abortion 1 16.92 Low Low
Increased Venous Pressure Under Development 13 5.00 Very Low Very Low Very Low
Hypertension 5 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We stimulated HK cells with various inflammatory cytokines but, none of the tested stimuli modulated PGIS expression significantly.
Regulation (modulated) of Gene_expression (expression) of PGIS associated with inflammation and cytokine
1) Confidence 0.23 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 17337058 Disease Relevance 0.29 Pain Relevance 0.19
The levels of PGIS protein expression did not vary during the different stages of the cell cycle.
Neg (not) Regulation (vary) of Gene_expression (expression) of PGIS
2) Confidence 0.23 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 17337058 Disease Relevance 0.26 Pain Relevance 0.12
The latter two results underline the importance of the vasodilatory effect which bradykinin has on eNOS activity, but they question the respective effect on prostacyclin production (cf. chapter on General Aspects of Vasodilatory Systems: Kallikrein-Kinin System).


Regulation (effect) of Gene_expression (production) of prostacyclin associated with bradykinin
3) Confidence 0.06 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.18 Pain Relevance 0.22

General Comments

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