INT14246

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Context Info
Confidence 0.44
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.04
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 7 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
Osteoarthritis 54 99.28 Very High Very High Very High
cytokine 73 98.32 Very High Very High Very High
Pain 1 98.32 Very High Very High Very High
Inflammation 48 96.24 Very High Very High Very High
spondylitis 1 84.24 Quite High
diclofenac 2 83.28 Quite High
anakinra 1 78.76 Quite High
Analgesic 1 59.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 56 100.00 Very High Very High Very High
Sepsis 2 99.72 Very High Very High Very High
Osteoarthritis 57 99.28 Very High Very High Very High
Pain 1 98.32 Very High Very High Very High
Anaplastic Astrocytoma 3 97.80 Very High Very High Very High
Disease 20 96.72 Very High Very High Very High
Disease Progression 2 94.24 High High
Diabetes Mellitus 4 86.52 High High
Tendinopathy 1 85.48 High High
Low Back Pain 2 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this respect, the profile of systemic cytokines' changes in response to exercise differs from that observed in sepsis, where there is a relevant increase in both serum IL-1?
Regulation (is) of Positive_regulation (increase) of IL-1 associated with sepsis and cytokine
1) Confidence 0.44 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 1.17 Pain Relevance 0.34
No NSAID showed significant effects on basal and IL-1beta stimulated IL-8 production, except CELE and IBUP, which slightly increased basal IL-8 production.
Neg (except) Regulation (effects) of Positive_regulation (stimulated) of IL-1beta
2) Confidence 0.44 Published 2002 Journal J. Rheumatol. Section Body Doc Link 11950021 Disease Relevance 0 Pain Relevance 0
In the present study, the effects of seven non-steroidal anti-inflammatory drugs (NSAIDs) on interleukin-1 beta (IL-1 beta)-induced IL-6 mRNA expression and protein synthesis in a human astrocytoma cell line were investigated.
Spec (investigated) Regulation (effects) of Spec (investigated) Positive_regulation (-induced) of IL-1 associated with anaplastic astrocytoma, inflammation and cinod
3) Confidence 0.32 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817534 Disease Relevance 0.65 Pain Relevance 0.50
Electrophoretic mobility shift and reporter gene assays revealed that tepoxalin exerts its inhibitory effect through the inhibition of nuclear factor kappaB (NF-kappaB), a transcription factor involved in the induction of IL-1, IL-6 and ACT gene expression.
Regulation (involved) of Positive_regulation (induction) of IL-1
4) Confidence 0.16 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10471086 Disease Relevance 0.43 Pain Relevance 0.40
With respect to the upregulation of IL-1?
Regulation (respect) of Positive_regulation (upregulation) of IL-1
5) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.80 Pain Relevance 0.43
Systemic concentrations of tumour necrosis factor alpha (TNF), interleukin-1 beta (IL-1), interleukin-6 (IL-6), cortisol, epinephrine and norepinephrine were measured before and during the operation and subsequently for up to 48 h postoperatively.
Regulation (measured) of Positive_regulation (concentrations) of interleukin-1 beta
6) Confidence 0.05 Published 1999 Journal Acta Anaesthesiol Scand Section Body Doc Link 10027020 Disease Relevance 0 Pain Relevance 0
Systemic concentrations of tumour necrosis factor alpha (TNF), interleukin-1 beta (IL-1), interleukin-6 (IL-6), cortisol, epinephrine and norepinephrine were measured before and during the operation and subsequently for up to 48 h postoperatively.
Regulation (measured) of Positive_regulation (concentrations) of IL-1
7) Confidence 0.05 Published 1999 Journal Acta Anaesthesiol Scand Section Body Doc Link 10027020 Disease Relevance 0 Pain Relevance 0
We have studied the effects of natural opioids on interleukin-1 (IL-1) -induced interleukin 2 (IL-2) production by the lymphoid cell line EL-4. beta-Endorphin (beta-end) significantly enhanced IL-2 production by IL-1-stimulated EL-4 cells.
Regulation (effects) of Positive_regulation (-induced) of interleukin-1 associated with opioid
8) Confidence 0.01 Published 1990 Journal Immunopharmacology Section Abstract Doc Link 1689707 Disease Relevance 0 Pain Relevance 0.10

General Comments

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