INT142461

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.06
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
astrocytes 4
liver 2
fibroblasts 2
T cells 2
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 14 99.62 Very High Very High Very High
fibrosis 37 97.60 Very High Very High Very High
cINOD 90 89.88 High High
chemokine 18 89.00 High High
Inflammation 109 83.44 Quite High
cytokine 39 77.80 Quite High
Hippocampus 8 70.16 Quite High
agonist 4 58.08 Quite High
addiction 2 18.88 Low Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 20 100.00 Very High Very High Very High
Hepatotoxicity 8 99.92 Very High Very High Very High
Lymphatic System Cancer 23 99.12 Very High Very High Very High
Fibrosis 35 97.60 Very High Very High Very High
Respiratory Syncytial Virus 102 93.68 High High
Obesity 2 92.64 High High
Apoptosis 29 92.52 High High
Targeted Disruption 40 90.72 High High
Cancer 154 84.44 Quite High
INFLAMMATION 124 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of STAT1 that is harmful in liver injury was augmented in SOCS3Tg hepatocytes.
Positive_regulation (augmented) of Positive_regulation (Activation) of STAT1 in liver associated with injury
1) Confidence 0.54 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.90 Pain Relevance 0.53
IFN-mediated STAT1 transcriptional induction results in the transcription of several hundred genes designated the Interferon-Stimulated Genes (ISG; see [8], [31], [32] for reviews).
Positive_regulation (results) of Positive_regulation (induction) of STAT1
2) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.14 Pain Relevance 0
Altogether, these results suggest that forced expression of SOCS3 in T cells is deleterious in APAP hepatotoxicity by increasing STAT1 activation while decreasing STAT3 activation in hepatocytes, possibly through elevated IFN-gamma and TNF-alpha.
Positive_regulation (increasing) of Positive_regulation (activation) of STAT1 in T cells associated with paracetamol and hepatotoxicity
3) Confidence 0.39 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.64 Pain Relevance 0.27
-mediated activation of JAK2 and ERK1/2, STAT1 binds to BACE1 promoter region to increase BACE1 protein expression in astrocytes [91].
Positive_regulation (increase) of Positive_regulation (activation) of STAT1 in astrocytes
4) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.79 Pain Relevance 0.40
-mediated activation of JAK2 and ERK1/2, STAT1 binds to BACE1 promoter region to increase BACE1 protein expression in astrocytes [91].
Positive_regulation (mediated) of Positive_regulation (activation) of STAT1 in astrocytes
5) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.78 Pain Relevance 0.40
We have also reported that V2O5 is a potent activator of type I IFN production by lung fibroblasts that leads to STAT-1 activation and proposed this mechanism in the resolution V2O5-induced fibrosis [22].
Positive_regulation (leads) of Positive_regulation (activation) of STAT-1 in fibroblasts associated with fibrosis
6) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.44 Pain Relevance 0.35
They found higher levels of activated STAT1, STAT3, and STAT5 in lymphoma cell lines that poorly responded to Vorinostat treatment compared to sensitive cell lines.
Positive_regulation (levels) of Positive_regulation (activated) of STAT1 associated with lymphatic system cancer
7) Confidence 0.14 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.38 Pain Relevance 0

General Comments

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