INT142464

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 58
Total Number 59
Disease Relevance 52.04
Pain Relevance 15.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Socs3) cytoplasm (Socs3)
Anatomy Link Frequency
T cells 7
extracellular matrix 4
macrophages 2
intestine 2
lung 2
Socs3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1401 100.00 Very High Very High Very High
Inflammation 1245 99.42 Very High Very High Very High
Paracetamol 40 99.04 Very High Very High Very High
rheumatoid arthritis 308 98.68 Very High Very High Very High
Arthritis 198 98.40 Very High Very High Very High
chemokine 85 98.22 Very High Very High Very High
agonist 44 97.76 Very High Very High Very High
fibrosis 167 97.24 Very High Very High Very High
Crohn's disease 37 92.76 High High
Inflammatory response 72 92.52 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 238 99.98 Very High Very High Very High
T-cell Lymphoma 18 99.96 Very High Very High Very High
Inflammatory Bowel Disease 133 99.64 Very High Very High Very High
Coronary Heart Disease 33 99.64 Very High Very High Very High
Blast Crisis 18 99.56 Very High Very High Very High
Colorectal Cancer 239 99.48 Very High Very High Very High
INFLAMMATION 1299 99.42 Very High Very High Very High
Eczema 18 99.36 Very High Very High Very High
Synovitis 23 99.34 Very High Very High Very High
Adenoma 412 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on these studies, we investigated SOCS3 mRNA expression in the normal mucosa of patients undergoing routine screening colonoscopy to determine if low SOCS3 predisposes to adenoma and could thus be considered an early biomarker of CRC risk.


Spec (investigated) Gene_expression (expression) of SOCS3 mRNA associated with colorectal cancer and adenoma
1) Confidence 0.77 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883989 Disease Relevance 1.11 Pain Relevance 0.24
However, our study found that low or silenced SOCS3 expression does not occur in the normal mucosa of patients with colorectal adenoma.
Gene_expression (expression) of SOCS3 associated with adenoma
2) Confidence 0.77 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883989 Disease Relevance 1.49 Pain Relevance 0.20
Finally, while our results could indicate that SOCS3 is more important in the underlying pathogenesis of inflammation-associated rather than sporadic CRC, recent studies comparing SOCS3 expression in both ulcerative colitis-associated and sporadic tumors found that SOCS3 was decreased and there was no significant difference between the two groups for SOCS3 [2].
Gene_expression (expression) of SOCS3 associated with colorectal cancer, inflammatory bowel disease, inflammation and cancer
3) Confidence 0.77 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883989 Disease Relevance 1.03 Pain Relevance 0.05
One potential limitation of the study is possible effect of standard bowel preparation on SOCS3 expression.
Gene_expression (expression) of SOCS3 in bowel
4) Confidence 0.77 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883989 Disease Relevance 1.39 Pain Relevance 0.18
Alternatively, hepatoprotective STAT3 activation was decreased in SOCS3Tg hepatocytes, an event that was associated with augmented SOCS3 expression in the hepatocytes.
Gene_expression (expression) of SOCS3 in hepatocytes
5) Confidence 0.76 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.73 Pain Relevance 0.32
Altogether, these results suggest that forced expression of SOCS3 in T cells is deleterious in APAP hepatotoxicity by increasing STAT1 activation while decreasing STAT3 activation in hepatocytes, possibly through elevated IFN-gamma and TNF-alpha.
Gene_expression (expression) of SOCS3 in T cells associated with paracetamol and hepatotoxicity
6) Confidence 0.76 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.71 Pain Relevance 0.32
Adaptive transfer of SOCS3Tg-CD4(+) T cells into T and B cell-deficient RAG-2(-/-) mice resulted in an exacerbated liver injury relative to the control.
Gene_expression (transfer) of SOCS3Tg in RAG associated with injury
7) Confidence 0.76 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.84 Pain Relevance 0.64
Mice with a cell-specific overexpression of SOCS3 in T cells (SOCS3Tg, in which Tg is transgenic) exhibited exaggerated hepatic injury after APAP challenge, as evidenced by increased serum alanine aminotransferase levels, augmented hepatic necrosis, and decreased survival relative to the wild-type mice.
Gene_expression (overexpression) of SOCS3 in T cells associated with targeted disruption, necrosis, paracetamol and injury
8) Confidence 0.76 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.78 Pain Relevance 0.70
The effect produced by GW3965 on glucose uptake was parallel to a downregulation of socs3 and ptp1b gene expression and to the recovery of insulin phosphorylation of AKT (Fig. 7).
Gene_expression (expression) of socs3
9) Confidence 0.73 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.40 Pain Relevance 0.26
Another possible limitation is that SOCS3 mRNA levels do not reflect changes in SOCS3 phosphorylation, which leads to its targeting for proteasomal degradation [19].
Gene_expression (levels) of SOCS3 mRNA
10) Confidence 0.67 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883989 Disease Relevance 1.26 Pain Relevance 0.12
The expression of STAT3 and SOCS3 mRNA was also significantly increased 24 h after LPS injection in both genotypes compared to the vehicle-injected COX-2+/+ mice (Fig. 6B and 6C), but the increase was significantly higher in COX-2-/- mice than in COX-2+/+ mice.
Gene_expression (expression) of SOCS3 mRNA
11) Confidence 0.65 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.17 Pain Relevance 0.13
In a dextran sulfate sodium-induced mouse colitis model, a time-course experiment indicated that STAT3 activation was 1 day ahead of SOCS3 induction; STAT3 activation became apparent during days 3 to 5 and decreased thereafter, whereas SOCS3 expression was induced at day 5 and maintained high levels thereafter.
Gene_expression (expression) of SOCS3 associated with colitis
12) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.58 Pain Relevance 0.44
In contrast, the enhanced action of SOCS3 may promote allergic responses, because a recent analysis indicated that transgenic SOCS3 expression in T cells inhibits Th1 development and promotes Th2 development [80].
Gene_expression (expression) of SOCS3 in T cells associated with targeted disruption and hypersensitivity
13) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.78 Pain Relevance 0.37
We have shown that overexpression of SOCS3 by adenoviral gene transfer could prevent the development of experimental arthritis [77].
Gene_expression (overexpression) of SOCS3 associated with experimental arthritis and arthritis
14) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.38 Pain Relevance 0.46
In murine models of inflammatory synovitis, STAT3 phosphorylation preceded SOCS3 expression, which is consistent with the idea that SOCS3 is part of the STAT3 negative-feedback loop [76].
Gene_expression (expression) of SOCS3 associated with inflammation and synovitis
15) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.44 Pain Relevance 0.44
In STAT1-/- mice, gene expression of synovial SOCS1, but not that of SOCS3, was markedly reduced in STAT1-deficient mice.
Gene_expression (expression) of SOCS3
16) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.64 Pain Relevance 0.67
In chronic myelogenous leukemia cells, especially in cells in blast crisis and T cell lymphoma, SOCS3 is expressed constitutively and may confer resistance to IFN therapy [95,96].
Gene_expression (expressed) of SOCS3 in T cell associated with t-cell lymphoma, blast crisis and chronic myeloid leukemia
17) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.12 Pain Relevance 0.03
Indeed, that report also describes that increased SOCS3 expression in T cells is correlated with the severity of human allergic diseases such as asthma and atopic dermatitis.
Gene_expression (expression) of SOCS3 in T cells associated with asthma, hypersensitivity, eczema and disease
18) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.84 Pain Relevance 0.35
STAT3 activation and high SOCS3 expression levels have been found in epithelial and lamina propria cells in the colon of IBD (inflammatory bowel disease) model mice, as well as in human ulcerative colitis and patients with Crohn's disease [76], and in synovial fibroblasts of patients with RA [77].
Gene_expression (expression) of SOCS3 in lamina associated with inflammatory bowel disease, crohn's disease, inflammation, rheumatoid arthritis and disease
19) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.79 Pain Relevance 0.55
On the basis of the evidence that forced expression of SOCS3 can inhibit IL-6-mediated STAT3 activation, we propose that SOCS3 is a negative regulator of inflammatory diseases in synovial fibroblasts, especially in those in which IL-6 levels are very high.
Gene_expression (expression) of SOCS3 in fibroblasts associated with inflammation and disease
20) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.47 Pain Relevance 0.45

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