INT142465

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 8.31
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Socs3) cytoplasm (Socs3)
Anatomy Link Frequency
hepatocytes 1
Socs3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 262 100.00 Very High Very High Very High
Inflammatory response 14 98.32 Very High Very High Very High
Inflammation 292 97.12 Very High Very High Very High
Arthritis 18 90.44 High High
rheumatoid arthritis 40 88.48 High High
fibrosis 14 87.00 High High
Paracetamol 7 84.80 Quite High
Crohn's disease 10 79.76 Quite High
cINOD 10 13.04 Low Low
agonist 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 110 99.76 Very High Very High Very High
Adenoma 60 99.76 Very High Very High Very High
Inflammatory Bowel Disease 38 99.14 Very High Very High Very High
Obesity 16 98.76 Very High Very High Very High
Diabetes Mellitus 8 98.52 Very High Very High Very High
INFLAMMATION 298 97.96 Very High Very High Very High
Colorectal Cancer 36 97.74 Very High Very High Very High
Shock 12 96.72 Very High Very High Very High
Injury 29 96.32 Very High Very High Very High
Hyperlipidemia 4 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is because SOCS3 is a relatively specific inhibitor of gp130 as described above.
Negative_regulation (inhibitor) of SOCS3
1) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.73 Pain Relevance 0.55
Finally, while our results could indicate that SOCS3 is more important in the underlying pathogenesis of inflammation-associated rather than sporadic CRC, recent studies comparing SOCS3 expression in both ulcerative colitis-associated and sporadic tumors found that SOCS3 was decreased and there was no significant difference between the two groups for SOCS3 [2].
Negative_regulation (decreased) of SOCS3 associated with colorectal cancer, inflammatory bowel disease, inflammation and cancer
2) Confidence 0.43 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883989 Disease Relevance 0.98 Pain Relevance 0.05
SOCS3 has been shown to limit the actions of both of these cytokines as well as their downstream targets STAT3 and NF?
Negative_regulation (limit) of SOCS3 associated with cytokine
3) Confidence 0.43 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883989 Disease Relevance 1.16 Pain Relevance 0.27
Alternatively, hepatoprotective STAT3 activation was decreased in SOCS3Tg hepatocytes, an event that was associated with augmented SOCS3 expression in the hepatocytes.
Negative_regulation (decreased) of SOCS3Tg in hepatocytes
4) Confidence 0.36 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.80 Pain Relevance 0.37
A decrease in SOCS1 and SOCS3 by antisense RNA treatment in obese diabetic mice improved insulin sensitivity and ameliorated hepatic steatosis and hypertriglyceridemia [100].
Negative_regulation (decrease) of SOCS3 associated with diabetes mellitus, obesity and hyperlipidemia
5) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.78 Pain Relevance 0.19
In STAT1-/- mice, gene expression of synovial SOCS1, but not that of SOCS3, was markedly reduced in STAT1-deficient mice.
Negative_regulation (reduced) of SOCS3
6) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.68 Pain Relevance 0.68
We also found a similar opposite relationship between STAT3 and SOCS3 on DC activation (Y Matsumura and A Yoshimura, unpublished data).
Negative_regulation (relationship) of SOCS3
7) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.33 Pain Relevance 0.19
One explanation involves the effects of suppressor of cytokine signaling 3 (SOCS3) on the IL-6 receptor.
Negative_regulation (suppressor) of SOCS3 associated with cytokine
8) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.42 Pain Relevance 0.16
One explanation involves the effects of suppressor of cytokine signaling 3 (SOCS3) on the IL-6 receptor.
Negative_regulation (suppressor) of cytokine signaling 3 associated with cytokine
9) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.42 Pain Relevance 0.16

General Comments

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