INT142477

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Context Info
Confidence 0.76
First Reported 2007
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 12
Total Number 17
Disease Relevance 12.53
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GP6)
Anatomy Link Frequency
platelet 11
coronary artery 1
GP6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 19 98.92 Very High Very High Very High
antagonist 12 90.80 High High
ischemia 6 80.80 Quite High
agonist 20 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 187 99.92 Very High Very High Very High
Thrombosis 17 99.92 Very High Very High Very High
Acute Coronary Syndrome 99 99.62 Very High Very High Very High
Cv General 3 Under Development 12 98.92 Very High Very High Very High
Coronary Artery Disease 13 98.56 Very High Very High Very High
Stable Angina Pectoris 7 98.20 Very High Very High Very High
Necrosis 6 97.52 Very High Very High Very High
Injury 6 96.28 Very High Very High Very High
Vasculitis 7 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelet GPVI expression in patients with ACS was compared to platelet count.
Gene_expression (expression) of GPVI in Platelet associated with acute coronary syndrome
1) Confidence 0.76 Published 2009 Journal Thromb. Haemost. Section Abstract Doc Link 19404545 Disease Relevance 0.93 Pain Relevance 0.09
Platelet surface expression of GPVI and CD62P was determined by flow cytometry and platelet count with a coulter counter, plasmatic soluble GPVI was measured by ELISA.
Gene_expression (expression) of GPVI in platelet
2) Confidence 0.76 Published 2009 Journal Thromb. Haemost. Section Abstract Doc Link 19404545 Disease Relevance 0.96 Pain Relevance 0.10
Influence of platelet count on the expression of platelet collagen receptor glycoprotein VI (GPVI) in patients with acute coronary syndrome.
Gene_expression (expression) of platelet collagen receptor glycoprotein VI in platelet associated with acute coronary syndrome
3) Confidence 0.76 Published 2009 Journal Thromb. Haemost. Section Title Doc Link 19404545 Disease Relevance 0.93 Pain Relevance 0.08
Influence of platelet count on the expression of platelet collagen receptor glycoprotein VI (GPVI) in patients with acute coronary syndrome.
Gene_expression (expression) of GPVI in platelet associated with acute coronary syndrome
4) Confidence 0.76 Published 2009 Journal Thromb. Haemost. Section Title Doc Link 19404545 Disease Relevance 0.93 Pain Relevance 0.08
Patients with ACS showed significantly elevated GPVI expression levels in the first and second quartiles of platelet count compared to patients with higher platelet count [mean fluorescence intensity (MFI) +/- standard deviation): 1(st) vs. 4(th): 20.44 +/- 6.1 vs. 18.62 +/- 3.7; p=0.012; 2(nd)vs.3(rd):21.2+/-8.5vs.18.76+/-3.7;P=0.03; 2(nd)vs.4(th): 21.2+/-8.5vs.18.62+/-3.7;P=0.004], which was paralleled in trend for the CD62P expression [MFI: 1(st) vs. 4(th): 11.2 +/- 6.8 vs. 12.3 +/- 9; p=0.057; 2(nd) vs. 3(rd): 16.3 +/- 16 vs.12.7 +/- 5.3; p=0.138; 2(nd) vs. 4(th): 16.3 +/- 16 vs.11 +/- 4.4; p=0.043].
Gene_expression (expression) of GPVI in platelet associated with acute coronary syndrome
5) Confidence 0.76 Published 2009 Journal Thromb. Haemost. Section Abstract Doc Link 19404545 Disease Relevance 0.95 Pain Relevance 0.09
Thus, a lower platelet count comes along with a higher GPVI surface expression and plasma concentration in patients with ACS, which potentially reflects increased activation and enhanced recruitment of platelets to the site of vascular injury.
Gene_expression (expression) of GPVI in platelets associated with acute coronary syndrome and vasculitis
6) Confidence 0.66 Published 2009 Journal Thromb. Haemost. Section Abstract Doc Link 19404545 Disease Relevance 0.52 Pain Relevance 0
We consecutively investigated both the platelet count and the platelet surface expression of GPVI in 843 patients with a symptomatic coronary artery disease verified by coronary angiography.
Gene_expression (expression) of GPVI in coronary artery associated with coronary artery disease
7) Confidence 0.66 Published 2009 Journal Thromb. Haemost. Section Abstract Doc Link 19404545 Disease Relevance 0.95 Pain Relevance 0.09
However, several D1D2 molecules may align and stack alongside each other, effectively increasing their overall affinity.16 That this may occur on a (GPP)10 sequence but not on shorter (GPP)5 ends of Toolkit peptides is consistent with the recent suggestion that a single GpVI molecule spans approximately 3 GXX?
Gene_expression (spans) of GpVI
8) Confidence 0.44 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.12 Pain Relevance 0
This spacing is too wide to accommodate a single GpVI,16 indicating 2 distinct GpVI loci on III-30.
Gene_expression (loci) of GpVI
9) Confidence 0.38 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.12 Pain Relevance 0
Platelet binding to III-30b was largely unaffected, making it an excellent GpVI substrate with only 2 HYP residues within 2 GPOGP motifs spaced 5 triplets apart, a feature it shares with III-26, which did not bind platelets.
Gene_expression (substrate) of GpVI in platelets
10) Confidence 0.38 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.14 Pain Relevance 0
Adhesion of recombinant GpVI ectodomains to Toolkit peptides
Gene_expression (ectodomains) of recombinant GpVI associated with adhesions
11) Confidence 0.38 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.40 Pain Relevance 0.05
Patients with ACS showed a significantly enhanced GPVI expression compared with patients with stable angina and healthy controls.
Gene_expression (expression) of GPVI associated with acute coronary syndrome and angina
12) Confidence 0.21 Published 2007 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 17340467 Disease Relevance 0.95 Pain Relevance 0.22
The expression of GPVI correlated well with CD62P.
Gene_expression (expression) of GPVI
13) Confidence 0.18 Published 2007 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 17340467 Disease Relevance 0.96 Pain Relevance 0.22
Elevated platelet GPVI expression was associated with ACS independent of markers of myocardial necrosis such as troponin and creatine kinase.
Gene_expression (expression) of GPVI in platelet associated with necrosis and acute coronary syndrome
14) Confidence 0.18 Published 2007 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 17340467 Disease Relevance 0.97 Pain Relevance 0.22
Surface expression of platelet activation markers such as P-selectin, GPIbalpha, and platelet GPVI was determined by flow cytometry.
Spec (determined) Gene_expression (expression) of GPVI in platelet
15) Confidence 0.18 Published 2007 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 17340467 Disease Relevance 0.94 Pain Relevance 0.19
In ACS, platelet surface GPVI expression was already elevated several hours before troponin and creatine kinase indicated myocardial injury.
Gene_expression (expression) of GPVI in platelet associated with acute coronary syndrome and injury
16) Confidence 0.18 Published 2007 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 17340467 Disease Relevance 0.96 Pain Relevance 0.21
GPVI platelet surface expression was examined in patients with stable angina and in patients with acute coronary syndrome (ACS).
Spec (examined) Gene_expression (expression) of GPVI in platelet associated with acute coronary syndrome and angina
17) Confidence 0.14 Published 2007 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 17340467 Disease Relevance 0.80 Pain Relevance 0.17

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