INT142478

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.50
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GP6)
Anatomy Link Frequency
platelet 10
GP6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 8 98.56 Very High Very High Very High
ischemia 3 82.48 Quite High
agonist 5 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 36 99.62 Very High Very High Very High
Cv General 3 Under Development 6 98.56 Very High Very High Very High
Necrosis 3 97.52 Very High Very High Very High
Injury 3 97.12 Very High Very High Very High
Vasculitis 2 94.04 High High
Thrombosis 6 87.80 High High
Stable Angina Pectoris 2 87.48 High High
Coronary Artery Disease 5 83.36 Quite High
Adhesions 47 76.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients with ACS showed significantly elevated GPVI expression levels in the first and second quartiles of platelet count compared to patients with higher platelet count [mean fluorescence intensity (MFI) +/- standard deviation): 1(st) vs. 4(th): 20.44 +/- 6.1 vs. 18.62 +/- 3.7; p=0.012; 2(nd)vs.3(rd):21.2+/-8.5vs.18.76+/-3.7;P=0.03; 2(nd)vs.4(th): 21.2+/-8.5vs.18.62+/-3.7;P=0.004], which was paralleled in trend for the CD62P expression [MFI: 1(st) vs. 4(th): 11.2 +/- 6.8 vs. 12.3 +/- 9; p=0.057; 2(nd) vs. 3(rd): 16.3 +/- 16 vs.12.7 +/- 5.3; p=0.138; 2(nd) vs. 4(th): 16.3 +/- 16 vs.11 +/- 4.4; p=0.043].
Positive_regulation (elevated) of Gene_expression (expression) of GPVI in platelet associated with acute coronary syndrome
1) Confidence 0.68 Published 2009 Journal Thromb. Haemost. Section Abstract Doc Link 19404545 Disease Relevance 0.95 Pain Relevance 0.09
Thus, a lower platelet count comes along with a higher GPVI surface expression and plasma concentration in patients with ACS, which potentially reflects increased activation and enhanced recruitment of platelets to the site of vascular injury.
Positive_regulation (higher) of Gene_expression (expression) of GPVI in platelets associated with acute coronary syndrome and vasculitis
2) Confidence 0.40 Published 2009 Journal Thromb. Haemost. Section Abstract Doc Link 19404545 Disease Relevance 0.52 Pain Relevance 0
Platelet binding to III-30b was largely unaffected, making it an excellent GpVI substrate with only 2 HYP residues within 2 GPOGP motifs spaced 5 triplets apart, a feature it shares with III-26, which did not bind platelets.
Positive_regulation (excellent) of Gene_expression (substrate) of GpVI in platelets
3) Confidence 0.28 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.14 Pain Relevance 0
Patients with ACS showed a significantly enhanced GPVI expression compared with patients with stable angina and healthy controls.
Positive_regulation (enhanced) of Gene_expression (expression) of GPVI associated with acute coronary syndrome and angina
4) Confidence 0.19 Published 2007 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 17340467 Disease Relevance 0.95 Pain Relevance 0.22
Elevated platelet GPVI expression was associated with ACS independent of markers of myocardial necrosis such as troponin and creatine kinase.
Positive_regulation (Elevated) of Gene_expression (expression) of GPVI in platelet associated with necrosis and acute coronary syndrome
5) Confidence 0.16 Published 2007 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 17340467 Disease Relevance 0.98 Pain Relevance 0.22
In ACS, platelet surface GPVI expression was already elevated several hours before troponin and creatine kinase indicated myocardial injury.
Positive_regulation (elevated) of Gene_expression (expression) of GPVI in platelet associated with acute coronary syndrome and injury
6) Confidence 0.16 Published 2007 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 17340467 Disease Relevance 0.96 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox